ReviewTrends in cardiovascular medicine2022
Importance of clonal hematopoiesis in heart failure.
Review in Trends in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Review
- Clonal hematopoiesis of indeterminate potential is associated with increased cardiovascular risk in chronic kidney disease.Clinical kidney journal · 2026Article
- Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Mortality in Patients with ESKD: A Pilot Case-Control Study.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- Impact of clonal hematopoiesis of indeterminate potential on prognosis in patients with severe aortic valve stenosis: a meta-analysis.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Immunometabolism in heart failure.Nature reviews. Cardiology · 2025Review
- Article
- Age-related cardiovascular disease and mosaic hematopoietic loss of the Y chromosome.The journal of cardiovascular aging · 2025Article
- Impact of age and sex on myelopoiesis and inflammation during myocardial infarction.Journal of molecular and cellular cardiology · 2024Review
- Role of serum cytokines in the prediction of heart failure in patients with coronary artery disease.ESC heart failure · 2023Article
- How clonal hematopoiesis promotes inflammation at a single-cell level.Nature cardiovascular research · 2023Article
- Inflammasomes and Atherosclerosis: a Mixed Picture.Circulation research · 2023Review
- Clonal Hematopoiesis: Connecting Aging and Inflammation in Atherosclerosis.Current atherosclerosis reports · 2023Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Heart failure is prevalent in the elderly population. Inflammatory processes can contribute to the progression of heart failure by altering the balance of tissue healing and pathological remodeling during the injury response. New findings show that aging can alter immune cell phenotypes through the process of clonal hematopoiesis. This condition results from acquired somatic DNA mutations in specific driver genes that give rise to clonal expansions of mutant hematopoietic cells with overactive inflammatory properties. Recent clinical and experimental studies have shown that clonal hematopoiesis is prevalent in heart failure patients and associated with poor prognosis. In this review, we summarize current evidence that associates clonal hematopoiesis with the progression of heart failure. We further describe the mechanistic links between clonal hematopoiesis and the pro-inflammatory responses that can contribute to pathological outcomes in the heart. Finally, we provide perspectives on future research directions in the area of clonal hematopoiesis and heart failure.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.