Evidence map›Paper›PMID 33892022›Full record

ArticleRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2021

Verification of field match lines in whole breast radiation therapy using Cherenkov imaging.

Rachael Hachadorian, J Cedar Farwell, Petr Bruza, Michael Jermyn, David J Gladstone, Brian W Pogue, Lesley A Jarvis

Abstract read
In one paragraph

Article in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rachael HachadorianThayer School of Engineering, Dartmouth College, Hanover, United States. Electronic address: Rachael.L.Hachadorian.TH@dartmouth.edu.
J Cedar FarwellDoseOptics LLC, Lebanon, United States.
Petr BruzaThayer School of Engineering, Dartmouth College, Hanover, United States.
Michael JermynThayer School of Engineering, Dartmouth College, Hanover, United States; DoseOptics LLC, Lebanon, United States.
David J GladstoneThayer School of Engineering, Dartmouth College, Hanover, United States; Norris Cotton Cancer Center at Dartmouth Hitchcock Medical Center, Lebanon, United States; Geisel School of Medicine, Dartmouth College, Hanover, United States.
Brian W PogueThayer School of Engineering, Dartmouth College, Hanover, United States; DoseOptics LLC, Lebanon, United States; Norris Cotton Cancer Center at Dartmouth Hitchcock Medical Center, Lebanon, United States; Geisel School of Medicine, Dartmouth College, Hanover, United States.
Lesley A JarvisNorris Cotton Cancer Center at Dartmouth Hitchcock Medical Center, Lebanon, United States; Geisel School of Medicine, Dartmouth College, Hanover, United States. Electronic address: Lesley.A.Jarvis@Hitchcock.org.

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Steven D Leach · 1985 to 2026
$91.3M
DoseRT™ : A Non-Contact Optical Patient and Beam Dosimetry System for Continuous in vivo Radiotherapy VerificationR44CA232879 · NCI · DOSEOPTICS, LLC · PI William Ware · 2018 to 2026
$5.2M
OPTICAL CHERENKOV IMAGING DOSIMETRY IN HUMAN RADIOTHERAPYR01EB023909 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI GLADSTONE, DAVID J., JARVIS, LESLEY A · 2017 to 2024
$4.4M
NCI NIH HHS P30 CA023108NCI NIH HHS R44 CA232879NIBIB NIH HHS R01 EB023909
6 · The paper itself

Abstract

purposeIn mono-isocentric radiation therapy treatment plans designed to treat the whole breast and supraclavicular lymph nodes, the fields meet at isocenter, forming the match line. Insufficient coverage at the match line can lead to recurrence, and overlap over weeks of treatment can lead to increased risk of healthy tissue toxicity. Cherenkov imaging was used to assess the accuracy of delivery at the match line and identify potential incidents during patient treatments. METHODS AND MATERIALS: A controlled calibration was constructed from the deconvolved Cherenkov images from the delivery of a modified patient treatment plan to an anthropomorphic phantom with introduced separation and overlap. The trend from this calibration was then used to evaluate the field match line for accuracy and inter-fraction consistency for two patients.

resultsThe intersection point between matching field profiles was directly correlated to the distance (gap/overlap) between the fields (anthropomorphic phantom R

conclusionsThis study shows that field match regions can be detected and quantified by taking deconvolved Cherenkov images and using their product image to create steep intensity gradients, causing match lines to stand out. These regions can then be quantitatively translated into a dose consequence. This approach offers a high sensitivity detection method which can quantify match line variability and errors in vivo.

Indexed as

Radiotherapy, Intensity-ModulatedRadiotherapy Planning, Computer-AssistedCalibrationHumansPhantoms, ImagingRadiotherapy DosageBreastCherenkovField MatchImagingIn vivoRadiation Therapy

Identifiers

PMID33892022
PMCPMC8686843

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.