ArticleThe Journal of allergy and clinical immunology2021
Acute FPIES reactions are associated with an IL-17 inflammatory signature.
Article in The Journal of allergy and clinical immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 63 citations in OpenAlex.
- Food protein-induced enterocolitis syndrome in children: An updated review on pathogenesis, diagnosis, and management.World journal of clinical pediatrics · 2026Review
- γδ T Cell-Mediated Neuroimmune Interactions in Skin Inflammation and Allergy.Clinical reviews in allergy & immunology · 2026Review
- Matrine Alleviates Atherosclerosis by Targeting REG1A and Activating the PI3K/AKT/mTOR Pathway to Inhibit Endothelial Cell Ferroptosis.Biochemical genetics · 2026Article
- Dupilumab opens a therapeutic window in food protein-induced enterocolitis syndrome by unlicensing dendritic cells.The journal of allergy and clinical immunology. Global · 2026Article
- Gut microbiota alters the Th1/Th2 balance and aggravates food-allergic enteropathy in a mouse model.Bioscience of microbiota, food and health · 2026Article
- REG/Reg family proteins: mediating gut microbiota homeostasis and implications in digestive diseases.Gut microbes · 2025Review
- Cytokine Variations After Positive Oral Food Challenges in Adult-Onset Food Protein-Induced Enterocolitis.Allergy · 2025Article
- Food Protein-Induced Enterocolitis Syndrome Across Lifespan: Focus on Adolescence.Journal of clinical medicine · 2025Review
- Sex-specific leukocyte responses to peanut allergen: uncovering potential links to the molecular circadian clock.Journal of leukocyte biology · 2025Article
- Food Allergenicity Evaluation Methods: Classification, Principle, and Applications.Foods (Basel, Switzerland) · 2025Review
- High-Fat Diet-Induced Mild Obesity Alters the Activation of T Cells and Maintains Intestinal Homeostasis in Food Allergy Animal Model.Foods (Basel, Switzerland) · 2025Article
- Association of myeloid cell reactivity patterns with safe food predictions in FPIES patients.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2025Article
- Identification of Gut Biomarkers of FPIES in a Longitudinal Comparative Pediatric Study.Allergy · 2025Article
- Neonatal Food Protein-Induced Enterocolitis: Current Insights and Knowledge Gaps.Journal of clinical medicine · 2025Review
- Serum biomarkers REG1A and REG3A combined with the traditional CEA represent a novel nomogram for the screening and risk stratification of colorectal cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Article
- Characterization of Mucosal Immune-Related lncRNAs and mRNAs in a Mouse Model of Allergic Conjunctivitis.Journal of inflammation research · 2025Article
- Differential DNA methylation in infants with IgE- and non-IgE-mediated cow's milk allergy and its association with acquired tolerance.Frontiers in immunology · 2025Article
- Review
- Contribution of T cell subsets to different food allergic diseases.Immunological reviews · 2024Review
- Mass Cytometry in Food Allergy Research.Methods in molecular biology (Clifton, N.J.) · 2024Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundFood protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy characterized by profuse vomiting within hours of ingestion of the causative food. We have previously reported that FPIES is associated with systemic innate immune activation in the absence of a detectable antigen-specific antibody or T-cell response. The mechanism of specific food recognition by the immune system remains unclear.
objectiveOur aim was to identify immune mechanisms underlying FPIES reactions by proteomic and flow cytometric analysis of peripheral blood.
methodsChildren with a history of FPIES underwent supervised oral food challenge. Blood samples were taken at baseline, at symptom onset, and 4 hours after symptom onset. We analyzed samples from 23 children (11 reactors and 12 outgrown). A total of 184 protein markers were analyzed by proximity ligation assay and verified by multiplex immunoassay. Analysis of cell subset activation was performed by mass cytometry and spectral cytometry.
resultsSymptomatic FPIES challenge results were associated with significant elevation of levels of cytokines and chemokines, including IL-17 family markers (IL-17A, IL-22, IL-17C, and CCL20) and T-cell activation (IL-2), and innate inflammatory markers (IL-8, oncostatin M, leukemia inhibitory factor, TNF-α, IL-10, and IL-6). The level of the mucosal damage marker regenerating family member 1 alpha (REG1A) was also significantly increased. These biomarkers were not increased in asymptomatic challenges or IgE-mediated allergy. The level of phospho-STAT3 was significantly elevated in myeloid and T cells after challenge in individuals with symptoms. Mass cytometry indicated preferential activation of nonconventional T-cell populations, including γδ T cells and CD3
conclusionsThese results demonstrate a unique IL-17 signature and activation of innate lymphocytes in FPIES.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.