Evidence map›Paper›PMID 33891944›Full record

ArticleThe Journal of biological chemistry

Dynamic allostery controls the peptide sensitivity of the Ly49C natural killer receptor.

Jiaqi Ma, Cory M Ayres, Lance M Hellman, Jason R Devlin, Brian M Baker

Open access · goldAbstract read
In one paragraph

Article in The Journal of biological chemistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jiaqi MaDepartment of Chemistry & Biochemistry and the Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana, USA.
Cory M AyresDepartment of Chemistry & Biochemistry and the Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana, USA.
Lance M HellmanDepartment of Physical and Life Sciences, Nevada State College, Henderson, Nevada, USA.
Jason R DevlinDepartment of Chemistry & Biochemistry and the Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana, USA.
Brian M BakerDepartment of Chemistry & Biochemistry and the Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana, USA. Electronic address: brian-baker@nd.edu.
University of Notre Dame · USNevada State University · US

Funding

Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Structural biophysics and molecular design in cellular immunityR35GM118166 · NIGMS · UNIVERSITY OF NOTRE DAME · PI BAKER, BRIAN M · 2016 to 2025
$4.4M
BIACORE T200 SPR FOR NOTRE DAME BIOPHYSICS INSTRUMENTATION CORE (BIC) FACILITYS10OD028553 · OD · UNIVERSITY OF NOTRE DAME · PI BAKER, BRIAN M · 2020 to 2020
$343k
NCATS NIH HHS UL1 TR002529NIGMS NIH HHS R35 GM118166NIH HHS S10 OD028553
6 · The paper itself

Abstract

Using a variety of activating and inhibitory receptors, natural killer (NK) cells protect against disease by eliminating cells that have downregulated class I major histocompatibility complex (MHC) proteins, such as in response to cell transformation or viral infection. The inhibitory murine NK receptor Ly49C specifically recognizes the class I MHC protein H-2K

Indexed as

Allosteric RegulationAnimalsKiller Cells, NaturalKineticsMiceModels, MolecularMolecular Dynamics SimulationNK Cell Lectin-Like Receptor Subfamily AProtein BindingProtein DomainsSubstrate SpecificityNK Cell Lectin-Like Receptor Subfamily Aallosteric regulationbindingelectrostaticsisothermal titration calorimetrylinkagemajor histocompatibility complexnatural killer cellsprotein dynamicsthermodynamics

Identifiers

PMID33891944
PMCPMC8138769
OpenAlexW3155894275

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.