ArticleImmunity2021
Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children.
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Article in Immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 170 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
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170citing papers in PubMed, 3 pooled it
46.6field-weighted citation impact, top 1% of its field
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The trial behind it
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Who cites it
170 citing papers in PubMed, 3 syntheses or guidelines pooled it, 254 citations in OpenAlex.
- Long-Term Complications of Multisystem Inflammatory Syndrome in Children and Adults Post-COVID-19: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- The protective effect of COVID-19 vaccines on developing multisystem inflammatory syndrome in children (MIS-C): a systematic literature review and meta-analysis.Pediatric rheumatology online journal · 2023Pooled it
- Cardiac sequelae after coronavirus disease 2019 recovery: a systematic review.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2021Pooled it
- Teplizumab induces persistent changes in the antigen-specific repertoire in individuals at risk for type 1 diabetes.The Journal of clinical investigation · 2024Trial
- Paediatric Healthcare Utilisation Trends From the Pre-Pandemic Period Through Two Years Post-COVID-19: Evidence From a Nationwide Big-Data Analysis.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Interpretable deep generative ensemble learning for single-cell omics with Hydra.Molecular systems biology · 2026Article
- Antibody repertoire associated with clinically diverse presentations of pediatric SARS-CoV-2 infection.Scientific reports · 2026Article
- Longitudinal Single-Cell Transcriptomic Profiling Reveals Dynamic Immune Cell Alterations During Burosumab Therapy in X-Linked Hypophosphatemia.Pediatric discovery · 2026Article
- Development of a pediatric immune cell atlas and characterization of CD4+ T cells in food allergy.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Review
- Widespread Molecular Imprints in the Serum Proteome of COVID-19 Convalescents Uncovering Immune System Sequelae.Molecular & cellular proteomics : MCP · 2026Article
- Shared TCR Vβ21.3+ T cell immunological signature between MIS-A and MIS-C.Journal of human immunity · 2026Article
- Neutrophil heterogeneity in Kawasaki disease and multisystem inflammatory syndrome in children.Pediatric research · 2026Review
- PBMCpedia: a harmonized PBMC scRNA-seq database with unified mapping and enhanced celltype annotation.Nucleic acids research · 2026Article
- The seven enigmas of SARS-CoV-2: from the past to the future.Journal of human immunity · 2025Article
- Polyclonal Vβ21.3 expansion in multisystem inflammatory syndrome in children despite SARS-CoV-2 vaccination.RMD open · 2025Article
- Article
- In depth characterisation of the proteome of MIS-C and post COVID-19 infection in children reveals inflammatory pathway activation and evidence of tissue damage.Journal of translational medicine · 2025Article
- Elevated neuroinflammation, autoimmunity, and altered IgG glycosylation profile in the cerebral spinal fluid of severe COVID-19 patients.Brain, behavior, and immunity · 2025Article
- Age-Specific Clinical and Laboratory Features and Renal Involvement in Children with MIS-C: A Single Tertiary Centre Experience from Vojvodina.Medicina (Kaunas, Lithuania) · 2025Article
- Differentiating Kawasaki Disease and Multisystem Inflammatory Syndrome in Children Using Blood Composite Scores: Insights into Clinical Outcomes and Predictive Indices.Pediatric cardiology · 2025Article
110 more citing papers are in PubMed but not listed here.
Corrections and comments
- Update of
Authors and funding
32 authors at 4 institutions in 1 country.
Anjali RamaswamyDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, 06519, USA.
Nina N BrodskyDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, 06519, USA; Department of Pediatrics, Yale University School of Medicine, New Haven, CT, 06520, USA.
Tomokazu S SumidaDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, 06519, USA; Department of Neurology, Yale University School of Medicine, New Haven, CT, 06520, USA.
Michela ComiDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, 06519, USA; Department of Neurology, Yale University School of Medicine, New Haven, CT, 06520, USA.
Hiromitsu AsashimaDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, 06519, USA; Department of Neurology, Yale University School of Medicine, New Haven, CT, 06520, USA.
Kenneth B HoehnDepartment of Pathology, Yale University School of Medicine, New Haven, CT, 06520, USA.
Ningshan LiDepartment of Biostatistics, Yale School of Public Health, New Haven, CT, 06520, USA.
Yunqing LiuDepartment of Biostatistics, Yale School of Public Health, New Haven, CT, 06520, USA.
Aagam ShahDepartment of Internal Medicine (Cardiology), Yale University School of Medicine, New Haven, CT, 06510, USA; Department of Computer Science, Yale University, New Haven, CT, 06520, USA.
Neal G RavindraDepartment of Internal Medicine (Cardiology), Yale University School of Medicine, New Haven, CT, 06510, USA; Department of Computer Science, Yale University, New Haven, CT, 06520, USA.
Jason BishaiDepartment of Internal Medicine (Cardiology), Yale University School of Medicine, New Haven, CT, 06510, USA; Department of Computer Science, Yale University, New Haven, CT, 06520, USA.
Alamzeb KhanDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT, 06520, USA.
William LauNIH Center for Human Immunology (CHI), NIAID, NIH, Bethesda, MD, 20892, USA; Multiscale Systems Biology Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD, 20892, USA.
Brian SellersNIH Center for Human Immunology (CHI), NIAID, NIH, Bethesda, MD, 20892, USA.
Neha BansalNIH Center for Human Immunology (CHI), NIAID, NIH, Bethesda, MD, 20892, USA; Multiscale Systems Biology Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD, 20892, USA.
Pamela GuerrerioFood Allergy Research Section, Laboratory of Allergic Diseases, NIAID, NIH, Bethesda, MD, 20892, USA.
Avraham UntermanSection of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New, Haven, CT, 06520, USA.
Victoria HabetDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT, 06520, USA.
Andrew J RiceDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, 06519, USA.
Jason CatanzaroDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT, 06520, USA.
Harsha ChandnaniDepartment of Pediatrics, Loma Linda School of Medicine, Loma Linda, CA, 92354, USA.
Merrick LopezDepartment of Pediatrics, Loma Linda School of Medicine, Loma Linda, CA, 92354, USA.
Naftali KaminskiSection of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New, Haven, CT, 06520, USA.
Charles S Dela CruzSection of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New, Haven, CT, 06520, USA.
John S TsangNIH Center for Human Immunology (CHI), NIAID, NIH, Bethesda, MD, 20892, USA; Multiscale Systems Biology Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD, 20892, USA.
Zuoheng WangDepartment of Biostatistics, Yale School of Public Health, New Haven, CT, 06520, USA.
Xiting YanDepartment of Biostatistics, Yale School of Public Health, New Haven, CT, 06520, USA; Department of Computer Science, Yale University, New Haven, CT, 06520, USA.
Steven H KleinsteinDepartment of Pathology, Yale University School of Medicine, New Haven, CT, 06520, USA; Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, 06511, USA.
David van DijkDepartment of Internal Medicine (Cardiology), Yale University School of Medicine, New Haven, CT, 06510, USA; Department of Computer Science, Yale University, New Haven, CT, 06520, USA.
Richard W PierceDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT, 06520, USA.
David A HaflerDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, 06519, USA; Department of Neurology, Yale University School of Medicine, New Haven, CT, 06520, USA.
Carrie L LucasDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, 06519, USA. Electronic address: carrie.lucas@yale.edu.
Yale University · USNational Institutes of Health · USLoma Linda University · USNational Institute of Allergy and Infectious Diseases · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MCenter for Human Immunology ZICAI001226 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI CHERRY, JAMES · 2018 to 2025
$34.1MINTERDISCIPLINARY IMMUNOLOGY TRAINING PROGRAMT32AI007019 · NIAID · YALE UNIVERSITY · PI Carrie L. Lucas, David G. Schatz · 1985 to 2026
$14.4MIntegrative analysis and modeling of human immune responses and pathologiesZIAAI001152 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI TSANG, JOHN · 2011 to 2022
$14.1MCOMPUTATIONAL TOOLS FOR THE ANALYSIS OF HIGH-THROUGHPUT IMMUNOGLOBULIN SEQUENCING EXPERIMENTSR01AI104739 · NIAID · YALE UNIVERSITY · PI KLEINSTEIN, STEVEN H. · 2014 to 2022
$3.6MCOVID vaccine-associated allergic reactionsZIAAI001336 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI FRISCHMEYER-GUERRERIO, PAMELA · 2021 to 2025
$1.9MSystems Immunology of COVID-19ZIAAI001266 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI TSANG, JOHN · 2020 to 2022
$1.2MMechanisms of immune dysregulation in human PI3Kgamma deficiencyR21AI144315 · NIAID · YALE UNIVERSITY · PI LUCAS, CARRIE L. · 2020 to 2021
$830kMechanisms of Endothelial Cell Dysfunction in Critically Ill ChildrenK08HL136898 · NHLBI · YALE UNIVERSITY · PI PIERCE, RICHARD W · 2019 to 2023
$780kDeep and Integrative Analysis of RNA Sequencing Data to Identify Pathogenesis Heterogeneity of Chronic Lung DiseaseR21LM012884 · NLM · YALE UNIVERSITY · PI YAN, XITING · 2018 to 2019
$415kNCATS NIH HHS UL1 TR001863NHLBI NIH HHS K08 HL136898NIAID NIH HHS R01 AI104739NIAID NIH HHS R21 AI144315NIAID NIH HHS T32 AI007019NLM NIH HHS R21 LM012884
Abstract
Multisystem inflammatory syndrome in children (MIS-C) is a life-threatening post-infectious complication occurring unpredictably weeks after mild or asymptomatic SARS-CoV-2 infection. We profiled MIS-C, adult COVID-19, and healthy pediatric and adult individuals using single-cell RNA sequencing, flow cytometry, antigen receptor repertoire analysis, and unbiased serum proteomics, which collectively identified a signature in MIS-C patients that correlated with disease severity. Despite having no evidence of active infection, MIS-C patients had elevated S100A-family alarmins and decreased antigen presentation signatures, indicative of myeloid dysfunction. MIS-C patients showed elevated expression of cytotoxicity genes in NK and CD8
Indexed as
AdolescentAlarminsAutoantibodiesCD8-Positive T-LymphocytesChildChild, PreschoolCOVID-19Cytotoxicity, ImmunologicEndotheliumHumansKiller Cells, NaturalMyeloid CellsPlasma CellsReceptors, Antigen, T-CellSARS-CoV-2Severity of Illness IndexAlarminsAutoantibodiesReceptors, Antigen, T-CellalarminscytotoxicityinflammationMIS-CpediatricplasmablastsSARS-CoV-2TRBV11-2
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