ArticleCell2021
Early introductions and transmission of SARS-CoV-2 variant B.1.1.7 in the United States.
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Article in Cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 1 of them a synthesis that pooled it.
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99citing papers in PubMed, 1 pooled it
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Who cites it
99 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Understanding the Secret of SARS-CoV-2 Variants of Concern/Interest and Immune Escape.Frontiers in immunology · 2021Pooled it
- Rapid Phylogeographic Inference of Regional Epidemic Dynamics for Routine Genomic Surveillance.Research square · 2026Article
- Containment of a Multi-index B.1.1.7 Outbreak on a University Campus Through a Genomically Informed Public Health Response.Open forum infectious diseases · 2026Article
- Quantifying the spatiotemporal dynamics of the first two epidemic waves of SARS-CoV-2 infections in the United States.PLoS computational biology · 2026Article
- Overview of SARS-CoV-2 genomic surveillance in Central America and the Dominican Republic from February 2020 to January 2023: the impact of PAHO and COMISCA's collaborative efforts.Frontiers in public health · 2026Article
- Disparities in COVID-19 mortality in the United States, 2020-2023.BMC public health · 2025Article
- Analysis of the prevalence, spread, and mutation patterns of SARS-CoV-2 variants: data from COVID-19 testing expansion strategy study in salvador, Northeast Brazil.Scientific reports · 2025Article
- Tracing SARS-CoV-2 clusters across local scales using genomic data.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Virus Detection by CRISPR-Cas9-Mediated Strand Displacement in a Lateral Flow Assay.ACS applied bio materials · 2025Article
- Characterizing spatial epidemiology in a heterogeneous transmission landscape using the spatial transmission count statistic.Communications medicine · 2025Article
- Large-Scale Genomic Analysis of SARS-CoV-2 Omicron BA.5 Emergence, United States.Emerging infectious diseases · 2025Article
- Effectiveness of mRNA COVID-19 Vaccines and Hybrid Immunity in Preventing SARS-CoV-2 Infection and Symptomatic COVID-19 Among Adults in the United States.The Journal of infectious diseases · 2025Article
- Article
- Phylogenetic insights into the early spread of the SARS-CoV-2 Alpha variant across Europe.Virus evolution · 2025Article
- The importance of epistasis in the evolution of viral pathogens.Virus evolution · 2025Review
- SARS-CoV-2 introductions to the island of Ireland: a phylogenetic and geospatiotemporal study of infection dynamics.Genome medicine · 2024Article
- From Emergence to Evolution: Dynamics of the SARS-CoV-2 Omicron Variant in Florida.Pathogens (Basel, Switzerland) · 2024Article
- SARS-CoV-2 Illumina GeNome Assembly Line (SIGNAL), a Snakemate workflow for rapid and bulk analysis of Illumina sequencing of SARS-CoV-2 genomes.NAR genomics and bioinformatics · 2024Article
- Routes of importation and spatial dynamics of SARS-CoV-2 variants during localized interventions in Chile.PNAS nexus · 2024Article
- Towards geospatially-resolved public-health surveillance via wastewater sequencing.Nature communications · 2024Article
39 more citing papers are in PubMed but not listed here.
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Authors and funding
50 authors.
Tara AlpertDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA.
Anderson F BritoDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA.
Erica Lasek-NesselquistWadsworth Center, New York State Department of Health, Albany, NY 12208, USA; Department of Biomedical Sciences, University at Albany, SUNY, Albany, NY 12222, USA.
Jessica RothmanDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA.
Andrew L ValesanoDepartment of Internal Medicine, Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA.
Matthew J MacKayTempus Labs, Chicago, IL 60654, USA.
Mary E PetroneDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA.
Mallery I BrebanDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA.
Anne E WatkinsDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA.
Chantal B F VogelsDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA.
Chaney C KalinichDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA.
Simon DellicourSpatial Epidemiology Lab (SpELL), Université Libre de Bruxelles, Bruxelles, Belgium; Laboratory of Clinical and Epidemiological Virology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Alexis RussellWadsworth Center, New York State Department of Health, Albany, NY 12208, USA.
John P KellyWadsworth Center, New York State Department of Health, Albany, NY 12208, USA.
Matthew ShudtWadsworth Center, New York State Department of Health, Albany, NY 12208, USA; Department of Biomedical Sciences, University at Albany, SUNY, Albany, NY 12222, USA.
Jonathan PlitnickWadsworth Center, New York State Department of Health, Albany, NY 12208, USA; Department of Biomedical Sciences, University at Albany, SUNY, Albany, NY 12222, USA.
Erasmus SchneiderWadsworth Center, New York State Department of Health, Albany, NY 12208, USA; Department of Biomedical Sciences, University at Albany, SUNY, Albany, NY 12222, USA.
William J FitzsimmonsDepartment of Internal Medicine, Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA.
Gaurav KhullarTempus Labs, Chicago, IL 60654, USA.
Jessica MettiTempus Labs, Chicago, IL 60654, USA.
Joel T DudleyTempus Labs, Chicago, IL 60654, USA.
Megan NashTempus Labs, Chicago, IL 60654, USA.
Nike BeaubierTempus Labs, Chicago, IL 60654, USA.
Jianhui WangDepartment of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA.
Chen LiuDepartment of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA.
Pei HuiDepartment of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA.
Anthony MuyombweConnecticut State Department of Public Health, Rocky Hill, CT 06067, USA.
Randy DowningConnecticut State Department of Public Health, Rocky Hill, CT 06067, USA.
Jafar RazeqConnecticut State Department of Public Health, Rocky Hill, CT 06067, USA.
Stephen M BartConnecticut State Department of Public Health, Rocky Hill, CT 06067, USA; Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.
Ardath GrillsCenters for Disease Control and Prevention, Atlanta, GA 30329, USA.
Stephanie M MorrisonCenters for Disease Control and Prevention, Atlanta, GA 30329, USA.
Steven MurphyMurphy Medical Associates, Greenwich, CT 06830, USA.
Caleb NealMurphy Medical Associates, Greenwich, CT 06830, USA.
Eva LaszloMurphy Medical Associates, Greenwich, CT 06830, USA.
Hanna RennertDepartment of Pathology and Laboratory Medicine, New York Presbyterian Hospital-Weill Cornell Medicine, New York, NY 10021, USA.
Melissa CushingDepartment of Pathology and Laboratory Medicine, New York Presbyterian Hospital-Weill Cornell Medicine, New York, NY 10021, USA.
Lars WestbladeDepartment of Pathology and Laboratory Medicine, New York Presbyterian Hospital-Weill Cornell Medicine, New York, NY 10021, USA.
Priya VeluDepartment of Pathology and Laboratory Medicine, New York Presbyterian Hospital-Weill Cornell Medicine, New York, NY 10021, USA.
Arryn CraneyDepartment of Pathology and Laboratory Medicine, New York Presbyterian Hospital-Weill Cornell Medicine, New York, NY 10021, USA.
Lin CongDepartment of Pathology and Laboratory Medicine, New York Presbyterian Hospital-Weill Cornell Medicine, New York, NY 10021, USA.
David R PeaperDepartments of Laboratory Medicine and of Medicine, Yale School of Medicine, New Haven, CT 06510, USA.
Marie L LandryDepartments of Laboratory Medicine and of Medicine, Yale School of Medicine, New Haven, CT 06510, USA.
Peter W CookCenters for Disease Control and Prevention, Atlanta, GA 30329, USA.
Joseph R FauverDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA.
Christopher E MasonTempus Labs, Chicago, IL 60654, USA; Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital-Weill Cornell Medicine, New York, NY 10021, USA.
Adam S LauringDepartment of Internal Medicine, Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA.
Kirsten St GeorgeWadsworth Center, New York State Department of Health, Albany, NY 12208, USA; Department of Biomedical Sciences, University at Albany, SUNY, Albany, NY 12222, USA. Electronic address: kirsten.st.george@health.ny.gov.
Duncan R MacCannellCenters for Disease Control and Prevention, Atlanta, GA 30329, USA. Electronic address: fms2@cdc.gov.
Nathan D GrubaughDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA; Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06510, USA. Electronic address: nathan.grubaugh@yale.edu.
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MMICHIGAN MEDICAL SCIENTIST TRAINING PROGRAMT32GM007863 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COLLINS, KATHLEEN L. · 1985 to 2024
$38.3MNRSA Training CoreTL1TR001864 · NCATS · YALE UNIVERSITY · PI CANTLEY, LLOYD G, EDELMAN, E. JENNIFER · 2016 to 2025
$9.9MShort-Term Reserch Training: Students in Health SchoolsT35HL007649 · NHLBI · YALE UNIVERSITY · PI Sarwat I Chaudhry, Erica L Herzog · 1987 to 2026
$5.7MNCATS NIH HHS TL1 TR001864NCATS NIH HHS UL1 TR001863NHLBI NIH HHS T35 HL007649NIGMS NIH HHS T32 GM007863
Abstract
The emergence and spread of SARS-CoV-2 lineage B.1.1.7, first detected in the United Kingdom, has become a global public health concern because of its increased transmissibility. Over 2,500 COVID-19 cases associated with this variant have been detected in the United States (US) since December 2020, but the extent of establishment is relatively unknown. Using travel, genomic, and diagnostic data, we highlight that the primary ports of entry for B.1.1.7 in the US were in New York, California, and Florida. Furthermore, we found evidence for many independent B.1.1.7 establishments starting in early December 2020, followed by interstate spread by the end of the month. Finally, we project that B.1.1.7 will be the dominant lineage in many states by mid- to late March. Thus, genomic surveillance for B.1.1.7 and other variants urgently needs to be enhanced to better inform the public health response.
Indexed as
COVID-19COVID-19 TestingModels, BiologicalSARS-CoV-2FemaleHumansMaleUnited StatesB.1.1.7community transmissionepidemiologyflight volumesgenomic surveillanceintroductionslineagephylogeneticsSARS-CoV-2variant
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.