Evidence map›Paper›PMID 33891562›Full record

ArticleAging2021

Age-related differences of genetic susceptibility to patients with acute lymphoblastic leukemia.

Qing Hao, Minyuan Cao, Chunlan Zhang, Dandan Yin, Yuelan Wang, Yuanxin Ye, Shan Zhao, Yunfan Yang, Ke-Ling Chen, Binwu Ying and 9 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 1 country.

Qing HaoDepartment of Thoracic Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Minyuan CaoDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
Chunlan ZhangDepartment of Hematology, West China Hospital, Sichuan University, Chengdu, China.
Dandan YinDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
Yuelan WangDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
Yuanxin YeDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
Shan ZhaoDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
Yunfan YangDepartment of Hematology, West China Hospital, Sichuan University, Chengdu, China.
Ke-Ling ChenDigestive Surgery Institute, West China Hospital, Sichuan University, Chengdu, China.
Binwu YingDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
Lanlan WangDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
Yiguan ZhangSichuan Center for Translational Medicine of Traditional Chinese Medicine, Institute of Translational Pharmacology, Sichuan Academy of Chinese Medicine Sciences, Chengdu, China.
Caigang XuDepartment of Hematology, West China Hospital, Sichuan University, Chengdu, China.
Yiping ZhuDepartment of Hematology/Oncology, West China Second Hospital, Sichuan University, Chengdu, China.
Yu WuDepartment of Hematology, West China Hospital, Sichuan University, Chengdu, China.
Ju GaoDepartment of Hematology/Oncology, West China Second Hospital, Sichuan University, Chengdu, China.
Jun-Ning ZhaoSichuan Center for Translational Medicine of Traditional Chinese Medicine, Institute of Translational Pharmacology, Sichuan Academy of Chinese Medicine Sciences, Chengdu, China.
Yan ZhangDepartment of Thoracic Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Xiaoxi LuDepartment of Hematology/Oncology, West China Second Hospital, Sichuan University, Chengdu, China.
Sichuan University · CNWest China Second University Hospital of Sichuan University · CNWest China Hospital of Sichuan University · CNSichuan Academy of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inherited predispositions to acute lymphoblastic leukemia have been well investigated in pediatric patients, but studies on adults, particularly Chinese patients, are limited. In this study, we conducted a genome-wide association study in 466 all-age Chinese patients with Acute lymphoblastic leukemia (ALL) and 1,466 non-ALL controls to estimate the impact of age on ALL susceptibility in the Chinese population. Among the 17 reported loci, 8 have been validated in pediatric and 1 in adult patients. The strongest association signal was identified at

Indexed as

Age FactorsAdultAsian PeopleChildChild, PreschoolDNA-Binding ProteinsFemaleGATA3 Transcription FactorGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMalePrecursor Cell Lymphoblastic Leukemia-LymphomaRisk FactorsTranscription FactorsDNA-Binding ProteinsGATA3 protein, humanGATA3 Transcription FactorTranscription Factorsacute lymphoblastic leukemiaage specificgenetic susceptibilitygenome-wide association study

Identifiers

PMID33891562
PMCPMC8148462
OpenAlexW3152820036

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.