ArticleScience immunology2021
Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage.
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In one paragraph
Article in Science immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Secondary injury and inflammation after intracerebral haemorrhage: a systematic review and meta-analysis of molecular markers in patient brain tissue.Journal of neurology, neurosurgery, and psychiatry · 2022Pooled it
- Hematoma Interleukin-1 Receptor Antagonist Concentrations Predict Long-Term Outcome in Acute Human Intracerebral Hemorrhage.Annals of neurology · 2026Trial
- Lactylation and N6-Methyladenosine RNA modification in neuropsychiatric sequelae after intracerebral hemorrhage: a hypothesis-generating metabolic-glial-circuit framework.Molecular biology reports · 2026Review
- Astrocyte-Microglia Crosstalk in Post-Hemorrhagic Neurovascular Microenvironment: Mechanistic Nodes, Cross-Stroke Comparisons, and Therapeutic Reprogramming.Translational stroke research · 2026Review
- Piezoelectric g-CMaterials today. Bio · 2026Article
- Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312.Annals of clinical and translational neurology · 2026Article
- Single-cell analysis of microglia and monocyte dynamics uncovers distinct TNF-driven neuroimmune signatures in humans after intracerebral hemorrhage.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Article
- Cytokine markers in intracerebral hemorrhage are linked to ventricular imaging and outcomes.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2026Article
- The Dual Role of VEGF in Intracerebral Haemorrhage: From Pathological Mechanisms to Therapeutic Opportunities.Revista de neurologia · 2026Review
- Molecular heterogeneity in human stroke - What can we learn from the peripheral blood transcriptome?Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- Nrf2 attenuates neuroinflammatory injury in intracerebral hemorrhage via an ASK1/JNK-related signaling pathway.Scientific reports · 2026Article
- Exosomes derived from human umbilical cord mesenchymal stem cells attenuate neuroinflammation in intracerebral hemorrhage rats by modulating lactylation modification.Journal of translational medicine · 2026Article
- Induction of activating transcription factor 3 (ATF3) in the cerebral cortex of a mouse model of blast-induced traumatic brain injury.Human cell · 2026Article
- Single-Cell Analysis of Microglia and Monocyte Dynamics Uncover Distinct TNF-α-driven Neuroimmune Signatures after Intracerebral Hemorrhage.bioRxiv : the preprint server for biology · 2026Article
- Time-dependent changes in monocyte subsets and gene expression patterns are associated with long-term recovery in patients with ischemic stroke.Research square · 2026Article
- Distinct Inflammatory Profiles in Angiography-Negative Subarachnoid Hemorrhage: A Focused Case Series.medRxiv : the preprint server for health sciences · 2026Article
- Intracerebral hemorrhage induces monocyte TNF signaling that is suppressed by Siponimod (BAF312): a single-cell transcriptomics study in patients.medRxiv : the preprint server for health sciences · 2026Article
- Brain Endothelial Soluble ST2 Production and Cerebral Edema in a Rat Model of Ischemic Stroke.Annals of neurology · 2026Article
- Single-cell and spatial transcriptomics reveal transplant-associated T cells and myeloid cells in human liver transplantation.Frontiers in immunology · 2026Article
- FOXO1-driven metabolic reprogramming of hematomal CD8Cellular & molecular immunology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors at 8 institutions in 2 countries.
Michael H AskenaseDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-5990-7289
Brittany A GoodsInstitute for Medical Engineering & Science (IMES) and Department of Chemistry, MIT, Cambridge, MA, USA.
Hannah E BeattyDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-0077-0270
Arthur F SteinschneiderDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.
Sofia E VelazquezDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-5954-3518
Artem OsherovDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-1595-4486
Margaret J LandreneauDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-6432-4889
Shaina L CarrollInstitute for Medical Engineering & Science (IMES) and Department of Chemistry, MIT, Cambridge, MA, USA.ORCID 0000-0002-8051-5850
Tho B TranDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-0973-2908
Victor S AvramDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-2315-6919
Riley S DrakeInstitute for Medical Engineering & Science (IMES) and Department of Chemistry, MIT, Cambridge, MA, USA.ORCID 0000-0002-0323-6137
G James GatterInstitute for Medical Engineering & Science (IMES) and Department of Chemistry, MIT, Cambridge, MA, USA.ORCID 0000-0002-4755-5420
Jordan A MasseyDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-6195-1801
Saravanan S KaruppagounderSperling Center for Hemorrhagic Stroke Recovery, Burke Neurological Institute at Weill Cornell Medicine, White Plains, NY, USA.
Rajiv R RatanSperling Center for Hemorrhagic Stroke Recovery, Burke Neurological Institute at Weill Cornell Medicine, White Plains, NY, USA.
Charles C MatoukDepartment of Neurosurgery, Yale School of Medicine, New Haven, CT, USA.
Kevin N ShethDepartment of Neurosurgery, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-2003-5473
Wendy C ZiaiDivision of Brain Injury Outcomes, Johns Hopkins University, Baltimore, MD, USA.
Adrian R Parry-JonesDivision of Cardiovascular Sciences, School of Medicine, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
Issam A AwadNeurovascular Surgery Program, Section of Neurosurgery, University of Chicago Pritzker School of Medicine, Chicago, IL, USA.
Mario ZuccarelloDepartment of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID 0000-0002-7892-7450
Richard E ThompsonDivision of Brain Injury Outcomes, Johns Hopkins University, Baltimore, MD, USA.
Jesse DawsonInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.ORCID 0000-0001-7532-2475
Daniel F HanleyDivision of Brain Injury Outcomes, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-9536-4258
J Christopher LoveKoch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA. lauren.sansing@yale.edu shalek@mit.edu clove@mit.edu.ORCID 0000-0003-0921-3144
Alex K ShalekInstitute for Medical Engineering & Science (IMES) and Department of Chemistry, MIT, Cambridge, MA, USA. lauren.sansing@yale.edu shalek@mit.edu clove@mit.edu.ORCID 0000-0001-5670-8778
Lauren H SansingDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA. lauren.sansing@yale.edu shalek@mit.edu clove@mit.edu.ORCID 0000-0002-6898-1680
MISTIE III Consortium
ICHseq investigators
ICHseq Investigators MISTIE III Investigators
Yale University · USJohns Hopkins University · USBroad Institute · USCornell University · USNational Health Service · GBUniversity of Cincinnati Medical Center · USUniversity of Chicago · USUniversity of Glasgow · GB
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MJohns Hopkins-Tufts Trial Innovation Center HEAL Pain ERN SupplementU24TR001609 · NCATS · JOHNS HOPKINS UNIVERSITY · PI HANLEY, DANIEL F · 2016 to 2022
$36.3MMISTIE III_ Lead Grant_ Cluster Application for the Clinical Coordinating CenterU01NS080824 · NINDS · JOHNS HOPKINS UNIVERSITY · PI HANLEY, DANIEL F · 2013 to 2017
$23.2MShort-Term Reserch Training: Students in Health SchoolsT35HL007649 · NHLBI · YALE UNIVERSITY · PI Sarwat I Chaudhry, Erica L Herzog · 1987 to 2026
$5.7MDynamic Neuroimmune Profiling in Patients with Acute Intracerebral HemorrhageR01NS097728 · NINDS · YALE UNIVERSITY · PI SANSING, LAUREN H · 2016 to 2020
$2.8MAn integrated multiplexed genomic assay for low input clinical samples1U24AI118672 · NIAID · BROAD INSTITUTE, INC. · PI SHALEK, ALEX K · 2015 to 2019
$2.0MCharacterizing spatio-temporal changes in immune cell landscapes of multiple sclerosis patients in response to B cell depletion with OcrelizumabF32AI136459 · NIAID · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GOODS, BRITTANY ANNE · 2018 to 2020
$184kNCATS NIH HHS U24 TR001609NCATS NIH HHS UL1 TR001863NHLBI NIH HHS T35 HL007649NIAID NIH HHS F32 AI136459NIAID NIH HHS U24 AI118672NINDS NIH HHS R01 NS097728NINDS NIH HHS U01 NS080824
Abstract
Opportunities to interrogate the immune responses in the injured tissue of living patients suffering from acute sterile injuries such as stroke and heart attack are limited. We leveraged a clinical trial of minimally invasive neurosurgery for patients with intracerebral hemorrhage (ICH), a severely disabling subtype of stroke, to investigate the dynamics of inflammation at the site of brain injury over time. Longitudinal transcriptional profiling of CD14
Indexed as
AdultAgedBrainCells, CulturedCerebral HemorrhageFemaleHealthy VolunteersHematomaHumansLongitudinal StudiesMacrophagesMaleMiddle AgedNeuroinflammatory DiseasesNeutrophilsPrimary Cell Culture
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.