ArticleIEEE transactions on ultrasonics, ferroelectrics, and frequency control2021
Focused Ultrasound Mechanical Disruption of Ex Vivo Rat Tendon.
Article in IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Application of Focused Ultrasound for the Treatment of Tendinopathy: An In Vivo Feasibility, Safety, and Efficacy Study.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Doppler-based assessment of boiling histotripsy-induced volumetric tissue liquefaction in vivo.Ultrasonics · 2025Article
- Monitoring Fractionation in Elastic Tissues Using High Frame-Rate Doppler Ultrasound.Ultrasound in medicine & biology · 2025Article
- Overview of Therapeutic Ultrasound Applications and Safety Considerations: 2024 Update.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025Review
- Focused ultrasound as an alternative to dry needling for the treatment of tendinopathies: A murine model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
- Biomechanical testing of ex vivo porcine tendons following high intensity focused ultrasound thermal ablation.PloS one · 2024Article
- Dual-frequency boiling histotripsy in an ex vivo bovine tendinopathy model.The Journal of the Acoustical Society of America · 2023Article
- The histotripsy spectrum: differences and similarities in techniques and instrumentation.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2023Review
- Article
- Ultrasound-Responsive Hydrogels for On-Demand Protein Release.ACS applied bio materials · 2022Article
- Effects of focused ultrasound and dry needling on tendon mechanical properties.Journal of biomechanics · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Around 30 million tendon injuries occur annually in the U.S. costing $ 114 billion. Conservative therapies, like dry needling, promote healing in chronically injured tendons by inducing microdamage but have mixed success rates. Focused ultrasound (fUS) therapy can noninvasively fractionate tissues through the creation, oscillation, and collapse of bubbles in a process termed histotripsy; however, highly collagenous tissues, like tendon, have shown resistance to mechanical fractionation. This study histologically evaluates whether fUS mechanical disruption is achievable in tendons. Ex vivo rat tendons (45 Achilles and 44 supraspinatus) were exposed to 1.5-MHz fUS operating with 0.1-10 ms pulses repeated at 1-100 Hz for 15-60 s with peak positive pressures <89 MPa and peak negative pressures <26 MPa; other tendons were exposed to dry needling or sham. Immediately after treatment, tendons were flash-frozen and stained with hematoxylin and eosin (H&E) or alpha-nicotinamide adenine dinucleotide diaphorase ( α -NADH-d) and evaluated by two reviewers blinded to the exposure conditions. Results showed successful creation of bubbles for all fUS-treated samples; however, not all samples showed histological injury. When the injury was detected, parameter sets with shorter pulses (0.1-1 ms), lower acoustic pressures, or reduced treatment times showed mechanical disruption in the form of fiber separation and fraying with little to no thermal injury. Longer pulses or treatment times showed a combination of mechanical and thermal injury. These findings suggest that mechanical disruption is achievable in tendons within a small window of acoustic parameters, supporting the potential of fUS therapy in tendon treatment.
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Registered trials
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