ArticleIEEE transactions on pattern analysis and machine intelligence2021
High Resolution, Deep Imaging Using Confocal Time-of-Flight Diffuse Optical Tomography.
Article in IEEE transactions on pattern analysis and machine intelligence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 44 citations in OpenAlex.
- Neuromorphic Optical Tracking and Imaging of Randomly Moving Targets Through Dynamic Dense Scattering Media.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
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- A Multitask CNN for Near-Infrared Probe: Enhanced Real-Time Breast Cancer Imaging.Sensors (Basel, Switzerland) · 2025Article
- Monte Carlo Simulation of the Effect of Melanin Concentration on Light-Tissue Interactions in Reflectance Pulse Oximetry.Sensors (Basel, Switzerland) · 2025Article
- Monitoring of neoadjuvant chemotherapy through time domain diffuse optics: breast tissue composition changes and collagen discriminative potential.Biomedical optics express · 2024Article
- Imaging inside highly scattering media using hybrid deep learning and analytical algorithm.Journal of biophotonics · 2023Article
- An Optical Sensory System for Assessment of Residual Cancer Burden in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy.Sensors (Basel, Switzerland) · 2023Article
- Unrolled-DOT: an interpretable deep network for diffuse optical tomography.Journal of biomedical optics · 2023Article
- High-Speed Time-Domain Diffuse Optical Tomography with a Sensitivity Equation-based Neural Network.IEEE transactions on computational imaging · 2023Article
- Sub-mm resolution tomographic imaging in turbid media by an ultra-high density multichannel approach.Biomedical optics express · 2022Article
- Algorithms and instrumentation for rapid spatial frequency domain fluorescence diffuse optical imaging.Journal of biomedical optics · 2022Article
- Common methods in mitochondrial research (Review).International journal of molecular medicine · 2022Article
- Advanced high resolution three-dimensional imaging to visualize the cerebral neurovascular network in stroke.International journal of biological sciences · 2022Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Light scattering by tissue severely limits how deep beneath the surface one can image, and the spatial resolution one can obtain from these images. Diffuse optical tomography (DOT) is one of the most powerful techniques for imaging deep within tissue - well beyond the conventional ∼ 10-15 mean scattering lengths tolerated by ballistic imaging techniques such as confocal and two-photon microscopy. Unfortunately, existing DOT systems are limited, achieving only centimeter-scale resolution. Furthermore, they suffer from slow acquisition times and slow reconstruction speeds making real-time imaging infeasible. We show that time-of-flight diffuse optical tomography (ToF-DOT) and its confocal variant (CToF-DOT), by exploiting the photon travel time information, allow us to achieve millimeter spatial resolution in the highly scattered diffusion regime ( mean free paths). In addition, we demonstrate two additional innovations: focusing on confocal measurements, and multiplexing the illumination sources allow us to significantly reduce the measurement acquisition time. Finally, we rely on a novel convolutional approximation that allows us to develop a fast reconstruction algorithm, achieving a 100× speedup in reconstruction time compared to traditional DOT reconstruction techniques. Together, we believe that these technical advances serve as the first step towards real-time, millimeter resolution, deep tissue imaging using DOT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.