ArticleAmerican journal of respiratory and critical care medicine2021
Hospital-Level Variation in Death for Critically Ill Patients with COVID-19.
Article in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study of the Treatment and Outcomes in Critically Ill Patients With COVID-19
Prospective Observational Study Examining Clinical Characteristics, Inflammatory Markers, Treatments and Outcomes of Patients Hospitalized for COVID-19 at the University of Michigan Healthcare System in Ann Arbor
Who cites it
32 citing papers in PubMed.
- COVID-19 Mortality in Swedish Intensive Care Units: A Multicenter Survival Analysis.Acta anaesthesiologica Scandinavica · 2026Article
- Predicting Outcome and Duration of Mechanical Ventilation in Acute Hypoxemic Respiratory Failure: The PREMIER Study.Journal of clinical medicine · 2025Article
- ARDS Subphenotypes as a Guide to Therapy and Enrollment into Therapeutic Trials: Not So Fast.Journal of clinical medicine · 2025Article
- Early Prediction of ICU Mortality in Patients with Acute Hypoxemic Respiratory Failure Using Machine Learning: The MEMORIAL Study.Journal of clinical medicine · 2025Article
- In-hospital mortality predictors among COVID-19 patients in the West Bank, Palestine: a multi-center retrospective cohort study.Frontiers in medicine · 2025Article
- World Pneumonia Day 2024: Fighting Pneumonia and Antimicrobial Resistance.American journal of respiratory and critical care medicine · 2024Article
- Social Disparities and Critical Illness during the Coronavirus Disease 2019 Pandemic: A Narrative Review.Critical care clinics · 2024Review
- Comparison of outcomes and characteristics of patients admitted to the ICU with COVID-19 and other community-acquired pneumonia based on propensity score matching.BMC infectious diseases · 2024Article
- Observational
- Implementation of a Virtual Interprofessional ICU Learning Collaborative: Successes, Challenges, and Initial Reactions From the Structured Team-Based Optimal Patient-Centered Care for Virus COVID-19 Collaborators.Critical care explorations · 2023Article
- ICU Mortality Across Prepandemic and Pandemic Cohorts in a Resource-Limited Setting: A Critical Care Resiliency Analysis From South Africa.CHEST critical care · 2023Article
- Building local decision-making competencies during COVID-19: Accelerating the transition from learning healthcare systems to learning health communities.Learning health systems · 2023Article
- Variations in COVID-19 Hospital Mortality by Patient Race/Ethnicity and Hospital Type in Illinois.Journal of racial and ethnic health disparities · 2023Article
- Assessment of Symptom, Disability, and Financial Trajectories in Patients Hospitalized for COVID-19 at 6 Months.JAMA network open · 2023Article
- Timing of invasive mechanical ventilation and death in critically ill adults with COVID-19: A multicenter cohort study.PloS one · 2023Article
- Ventilatory Parameters Measured After One Week of Mechanical Ventilation and Survival in COVID-19-Related ARDS.Respiratory care · 2023Article
- Transcriptomic clustering of critically ill COVID-19 patients.The European respiratory journal · 2023Article
- Hospital characteristics associated with COVID-19 mortality: data from the multicenter cohort Brazilian Registry.Internal and emergency medicine · 2022Article
- Care of the Seriously Ill Patient with SARS-CoV-2.The Medical clinics of North America · 2022Review
- Variation in the risk of death due to COVID-19: An international multicenter cohort study of hospitalized adults.Journal of hospital medicine · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
rationaleVariation in hospital mortality has been described for coronavirus disease 2019 (COVID-19), but the factors that explain these differences remain unclear.
objectiveOur objective was to utilize a large, nationally representative dataset of critically ill adults with COVID-19 to determine which factors explain mortality variability.
methodsIn this multicenter cohort study, we examined adults hospitalized in intensive care units with COVID-19 at 70 United States hospitals between March and June 2020. The primary outcome was 28-day mortality. We examined patient-level and hospital-level variables. Mixed-effects logistic regression was used to identify factors associated with interhospital variation. The median odds ratio (OR) was calculated to compare outcomes in higher- vs. lower-mortality hospitals. A gradient boosted machine algorithm was developed for individual-level mortality models. MEASUREMENTS AND MAIN
resultsA total of 4,019 patients were included, 1537 (38%) of whom died by 28 days. Mortality varied considerably across hospitals (0-82%). After adjustment for patient- and hospital-level domains, interhospital variation was attenuated (OR decline from 2.06 [95% CI, 1.73-2.37] to 1.22 [95% CI, 1.00-1.38]), with the greatest changes occurring with adjustment for acute physiology, socioeconomic status, and strain. For individual patients, the relative contribution of each domain to mortality risk was: acute physiology (49%), demographics and comorbidities (20%), socioeconomic status (12%), strain (9%), hospital quality (8%), and treatments (3%).
conclusionThere is considerable interhospital variation in mortality for critically ill patients with COVID-19, which is mostly explained by hospital-level socioeconomic status, strain, and acute physiologic differences. Individual mortality is driven mostly by patient-level factors. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.