Evidence map›Paper›PMID 33891368›Full record

ArticleVeterinary and comparative oncology2022

Feasibility and safety of whole lung irradiation in the treatment of canine appendicular osteosarcoma.

Amanda Brehm, Heather Wilson-Robles, Tasha Miller, Jill Jarvis, Michael Deveau

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary and comparative oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Amanda BrehmSmall Animal Clinical Sciences Department, Texas A&M University, College Station, Texas, USA.ORCID https://orcid.org/0000-0002-0895-3688
Heather Wilson-RoblesSmall Animal Clinical Sciences Department, Texas A&M University, College Station, Texas, USA.ORCID https://orcid.org/0000-0002-6489-8468
Tasha MillerSmall Animal Clinical Sciences Department, Texas A&M University, College Station, Texas, USA.
Jill JarvisSmall Animal Clinical Sciences Department, Texas A&M University, College Station, Texas, USA.
Michael DeveauSmall Animal Clinical Sciences Department, Texas A&M University, College Station, Texas, USA.ORCID https://orcid.org/0000-0001-5334-4702
Texas A&M University · US

Funding

American College of Veterinary Internal Medicine 535767Katherine and Rebecca Rochelle Chair in OncologyTexas A&M GINN Grant
6 · The paper itself

Abstract

Whole lung irradiation (WLI) has been used successfully in humans as an adjuvant treatment for osteosarcoma. The aim of this study is to describe the feasibility and safety of WLI in dogs with appendicular osteosarcoma. Twelve client-owned dogs with appendicular osteosarcoma that had successfully completed amputation and four doses of carboplatin without evidence of gross metastasis were enrolled in this prospective clinical trial. Ten once-daily fractions of 1.75 Gy were administered to the planning target volume encompassing the lungs. Overall, WLI was well tolerated in these patients. No dogs developed symptoms of pneumonitis or pulmonary fibrosis. Haematopoietic toxicity evaluated during radiation therapy was found to be mild. The median disease free interval for WLI treated dogs was not significantly different than the median DFI for a group of historic control dogs (376 days for WLI treated dogs versus 304.5 days for control dogs; p = 0.5461). Although no significant improvement in outcome was observed with this study, WLI appears to be safe in dogs and warrants further investigation to characterize the efficacy and toxicity.

Indexed as

Bone NeoplasmsDog DiseasesOsteosarcomaAnimalsDogsFeasibility StudiesHumansLungbone tumourclinical triallung radiation effectspulmonary metastasisradiation oncology

Identifiers

PMID33891368
PMCPMC9290556
OpenAlexW3152754280

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.