ReviewCognitive, affective & behavioral neuroscience2022
Early life stress and neural development: Implications for understanding the developmental effects of COVID-19.
Review in Cognitive, affective & behavioral neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Emotion regulation as mediator between childhood adversity and psychopathology: A meta-analysis.Clinical psychology review · 2022Pooled it
- Early Childhood Anxiety and Maternal Factors: Associations with State and Trait Anxiety in a Greek Cohort of Preschoolers.Medical sciences (Basel, Switzerland) · 2026Article
- COVID-19 hardship and mental health in Chilean parents: the role of disaster exposure and family resilience.European journal of psychotraumatology · 2025Article
- Article
- Early life stress and iron metabolism in developmental psychoneuroimmunology.Brain, behavior, & immunity - health · 2024Article
- Characterizing the mechanisms of social connection.Neuron · 2023Review
- Neural patterns of threat response in adolescents predict vulnerability for and resilience against internalizing symptoms during COVID-19 waves.Neuroimage. Reports · 2023Article
- The Interaction between Psychological Stress and Iron Status on Early-Life Neurodevelopmental Outcomes.Nutrients · 2023Review
- More than a year of pandemic: Longitudinal assessment of anxiety and depressive symptoms in the argentine general population during the COVID-19 outbreak.Stress and health : journal of the International Society for the Investigation of Stress · 2022Article
- The Pandemial babies: effects of maternal stress on temperament of babies gestated and born during the pandemic.Current psychology (New Brunswick, N.J.) · 2022Article
- Approach motivation and loneliness: Individual differences and parasympathetic activity.Psychophysiology · 2022Article
- Material hardship level and unpredictability in relation to U.S. households' family interactions and emotional well-being: Insights from the COVID-19 pandemic.Social science & medicine (1982) · 2022Article
- Early experience unpredictability in child development as a model for understanding the impact of the COVID-19 pandemic: A translational neuroscience perspective.Developmental cognitive neuroscience · 2022Article
- Social relationships and children's perceptions of adversity.Child development perspectives · 2021Article
- The impact of the COVID-19 pandemic on child and adolescent development around the world.Child development · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Chronic and/or extreme stress in childhood, often referred to as early life stress, is associated with a wide range of long-term effects on development. Given this, the COVID-19 pandemic has led to concern about how stress due to the pandemic will affect children's development and mental health. Although early life stress has been linked to altered functioning of a number of neural and biological systems, there is a wide range of variability in children's outcomes. The mechanisms that influence these individual differences are still not well understood. In the past, studies of stress in childhood focused on the type of events that children encountered in their lives. We conducted a review of the literature to formulate a new perspective on the effects of early life stress on development. This new, topological model, may increase understanding of the potential effects of the COVID-19 pandemic on children's development. This model is oriented on children's perceptions of their environment and their social relationships, rather than specific events. These factors influence central and peripheral nervous system development, changing how children interpret, adapt, and respond to potentially stressful events, with implications for children's mental and physical health outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.