Evidence map›Paper›PMID 33891249›Full record

ArticleJournal of materials science. Materials in medicine2021

Molecular insight into optimizing the N- and P-doped fullerenes for urea removal in wearable artificial kidneys.

Ahmad Miri Jahromi, Pegah Zandi, Mohammad Khedri, Ebrahim Ghasemy, Reza Maleki, Lobat Tayebi

Abstract read
In one paragraph

Article in Journal of materials science. Materials in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. A Comprehensive Review of Substitutional Silicon-Doped CMolecules (Basel, Switzerland) · 2025
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ahmad Miri JahromiComputational Biology and Chemistry Group (CBCG), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Pegah ZandiSchool of Metallurgy and Materials Engineering, College of Engineering, University of Tehran, Tehran, Iran.
Mohammad KhedriComputational Biology and Chemistry Group (CBCG), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Ebrahim GhasemyNanotechnology Department, School of New Technologies, Iran University of Science and Technology, Tehran, Iran.
Reza MalekiComputational Biology and Chemistry Group (CBCG), Universal Scientific Education and Research Network (USERN), Tehran, Iran. rezamaleki96@gmail.com.
Lobat TayebiMarquette University School of Dentistry, Milwaukee, WI, 53233, USA. lobat.tayebi@marquette.edu.ORCID http://orcid.org/0000-0003-1947-5658

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Urea is the result of the breakdown of proteins in the liver, the excess of which circulates in the blood and is adsorbed by the kidneys. However, in the case of kidney diseases, some products, specifically urea, cannot be removed from the blood by the kidneys and causes serious health problems. The end-stage renal disease (ESRD) patients are not able to purify their blood, which endangers their life. ESRD patients require dialysis, a costly and difficult method of urea removal from the blood. Wearable artificial kidneys (WAKs) are consequently designed to remove the waste from blood. Regarding the great amount of daily urea production in the body, WAKs should contain strong and selective urea adsorbents. Fullerenes-which possess fascinating chemical properties-have been considered herein to develop novel urea removal adsorbents. Molecular dynamics (MD) has enabled researchers to study the interaction of different materials and can pave the way toward facilitating the development of wearable devices. In this study, urea adsorption by N-doped fullerenes and P-doped fullerenes were assessed through MD simulations. The urea adsorption was simulated by five samples of fullerenes, with phosphorous and different nitrogen dopant contents. For comparing the urea adsorption capacity in the performed simulations, detailed characteristics-including the energy analysis, radius of gyration, radial distribution function (RDF), root-mean-square fluctuation (RMSD), and H-bond analyses were investigated. It had been determined that the fullerene containing 8% nitrogen-with the highest reduction in the radius of gyration, the maximum RDF, a high adsorption energy, and a high number of hydrogen bonds-adsorbs urea more efficiently.

Indexed as

Kidneys, ArtificialWearable Electronic DevicesAdsorptionBiocompatible MaterialsFullerenesHumansMaterials TestingNitrogenPhosphorusRenal DialysisUreaBiocompatible MaterialsFullerenesNitrogenPhosphorusUrea

Identifiers

PMID33891249
PMCPMC8065003

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.