ArticleSleep & breathing = Schlaf & Atmung2022
Impact of inflammatory markers on the relationship between sleep quality and diabetic kidney disease.
Article in Sleep & breathing = Schlaf & Atmung, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Sleep Quality and Its Independent Correlates in Patients with Diabetic Kidney Disease: A Retrospective Network.International journal of general medicine · 2026Article
- Exploring core and sentinel symptoms in elderly patients with type 2 diabetes through network analysis and the Apriori algorithm.Frontiers in medicine · 2026Article
- Association between sleep duration and estimated glomerular filtration rate in Chinese patients with diabetes: evidence from a cross-sectional study.European journal of medical research · 2025Observational
- Non-linear relationship between urinary creatinine and diabetic kidney disease: implications for clinical practice.BMC nephrology · 2025Article
- The association of sleep duration with the risk of chronic kidney disease: a systematic review and meta-analysis.Clinical kidney journal · 2024Article
- Correlation of plasma metabolites and comorbid illnesses with poor sleep quality in patients with coronary heart disease.Sleep & breathing = Schlaf & Atmung · 2023Article
- Establishment of a potent weighted risk model for determining the progression of diabetic kidney disease.Journal of translational medicine · 2023Article
- Association Between Sleep Duration and Albuminuria in Patients with Type 2 Diabetes: A Cross-Sectional Study in Ningbo, China.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Sleeping, Smoking, and Kidney Diseases: Evidence From the NHANES 2017-2018.Frontiers in medicine · 2021Article
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeBoth poor sleep and diabetic kidney disease are closely associated with inflammation. However, the correlation between poor sleep and diabetic kidney disease has not been well clarified. Thus, the aim of this study was to determine the mediating role that inflammatory markers play in the pathogenic effect of poor sleep on the severity of diabetic kidney disease (DKD).
methodsA cross-sectional survey was conducted on 336 patients with type 2 diabetes (T2D). DKD was diagnosed according to the guidelines of the National Kidney Foundation-Kidney Disease Outcome Quality Initiative (NKF-K/DOQI). The Pittsburg Sleep Quality Index (PSQI) score was applied to assess patients for the quality of their sleep. Patients with a PSQI score of more than 5 were assigned to the poor sleep group, and the rest of the patients were assigned to the good sleep group. Circulating levels of six inflammatory biomarkers related to poor sleep and DKD were measured.
resultsThe prevalence of DKD was higher in patients with poor sleep quality than in those with good sleep quality (42% vs. 25%, P = 0.002). After adjustment, poor sleep quality (PSQI score OR 1.075 [95%CI 1.018-1.135], P = 0.009) remained independently associated with DKD. PSQI score was found to be positively related to fibroblast growth factor (FGF23), interleukin 6 (IL-6), P-selectin, and intercellular adhesion molecule-1 (ICAM-1) (P < 0.01), rather than fibrinogen and C-reactive protein (CRP) in linear regression models. As revealed by multiple mediation analysis, FGF23 and IL-6 mediated 26% and 23% of the relationship between PSQI score and urinary microalbumin (UMA), respectively. Similarly, the FGF23 and ICAM-1, instead of IL-6 and P-selectin, mediated 32% and 24% of the association between PSQI and estimated glomerular filtration rate (eGFR), respectively.
conclusionsPoor sleep quality is independently associated with DKD. These results suggest that inflammatory markers contribute to a pathogenic connection between poor sleep and DKD.
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