ArticleBulletin of mathematical biology2021
Collective Oscillations in Coupled-Cell Systems.
Article in Bulletin of mathematical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Stoichiometric balance and sustained rhythms.Journal of mathematical biology · 2026Article
- Microfeature Segmentation Algorithm for Biological Images Using Improved Density Peak Clustering.Computational and mathematical methods in medicine · 2022Article
- Unstable eigenvectors and reduced amplitude spaces specifying limit cycles of coupled oscillators with simultaneously diagonalizable matrices: with applications from electric circuits to gene regulation.The European physical journal. B · 2022Article
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2 authors.
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Abstract
We investigate oscillations in coupled systems. The methodology is based on the Hopf bifurcation theorem and a condition extended from the Routh-Hurwitz criterion. Such a condition leads to locating the bifurcation values of the parameters. With such an approach, we analyze a single-cell system modeling the minimal genetic negative feedback loop and the coupled-cell system composed by these single-cell systems. We study the oscillatory properties for these systems and compare these properties between the model with Hill-type repression and the one with protein-sequestration-based repression. As the parameters move from the Hopf bifurcation value for single cells to the one for coupled cells, we compute the eigenvalues of the linearized systems to obtain the magnitude of the collective frequency when the periodic solution of the coupled-cell system is generated. Extending from this information on the parameter values, we further compute and compare the collective frequency for the coupled-cell system and the average frequency of the decoupled individual cells. To compare these scenarios with other biological oscillators, we perform parallel analysis and computations on a segmentation clock model.
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