ArticleClinical oral investigations2021
Remineralization effectiveness of adhesive containing amorphous calcium phosphate nanoparticles on artificial initial enamel caries in a biofilm-challenged environment.
Article in Clinical oral investigations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Mechanical properties and antibacterial efficacy against Streptococcus mutans biofilms of novel bioactive tooth root coatings in tooth-brushing simulation.Dental materials : official publication of the Academy of Dental Materials · 2026Article
- Article
- Advanced biomimetic mineralization approaches for enamel and dentin regeneration: a review.Odontology · 2026Review
- Learn from nature: Biomimetic nanocarriers for intracellular protein delivery.Bioactive materials · 2026Review
- Remineralization Potential of Casein Phosphopeptide-Amorphous Calcium Phosphate, Nanohydroxyapatite Crystals, and Bioactive Glass on Initial Enamel Lesions: A Systematic Review and Meta-analysis.International journal of clinical pediatric dentistry · 2025Article
- Size-controllable synthesis of hydroxyapatite nanorods via fluorine modulation: applications in dental adhesives for enhanced enamel remineralization.BMC oral health · 2025Article
- Advances in hybridized nanoarchitectures for improved oro-dental health.Journal of nanobiotechnology · 2024Review
- Resin infiltrant with antibacterial activity: effects of incorporation of DMAHDM monomer and NACP on physical and antimicrobial properties.Journal of applied oral science : revista FOB · 2024Article
- The preventive/therapeutic effect of COHeliyon · 2023Article
- Engineered Biomaterials Trigger Remineralization and Antimicrobial Effects for Dental Caries Restoration.Molecules (Basel, Switzerland) · 2023Review
- Inorganic Compounds as Remineralizing Fillers in Dental Restorative Materials: Narrative Review.International journal of molecular sciences · 2023Review
- Ceramic Nanomaterials in Caries Prevention: A Narrative Review.Nanomaterials (Basel, Switzerland) · 2022Review
- Multivalent network modifier upregulates bioactivity of multispecies biofilm-resistant polyalkenoate cement.Bioactive materials · 2022Article
- The power of weak ion-exchange resins assisted by amelogenin for natural remineralization of dental enamel: an in vitro study.Odontology · 2022Article
- Evaluation of the ability of adhesives with antibacterial and remineralization functions to prevent secondary caries in vivo.Clinical oral investigations · 2022Article
- Size Dependence of Particulate Calcium Phosphate Fillers in Dental Resin Composites.ACS omega · 2021Article
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Authors and funding
11 authors.
Funding
Abstract
objectivesDental caries is closely associated with acid-producing bacteria, and Streptococcus mutans is one of the primary etiological agents. Bacterial accumulation and dental demineralization lead to destruction of bonding interface, thus limiting the longevity of composite. The present study investigated remineralization effectiveness of adhesive containing nanoparticles of amorphous calcium phosphate (NACP) in a stimulated oral biofilm environment.
methodsThe enamel blocks were immersed in demineralization solution for 72 h to imitate artificial initial carious lesion and then subjected to a Streptococcus mutans biofilm for 24 h. All the samples then underwent 4-h demineralization in brain heart infusion broth with sucrose (BHIS) and 20-h remineralization in artificial saliva (AS) for 7 days. The daily pH of BHIS after 4-h incubation, lactic acid production, colony-forming unit (CFU) count, and content of calcium (Ca) and phosphate (P) in biofilm were evaluated. Meanwhile, the remineralization effectiveness of enamel was analyzed by X-ray diffraction (XRD), surface microhardness testing, transverse microradiography (TMR) and scanning electron microscopy (SEM).
resultsThe NACP adhesive released abundant Ca and P, achieved acid neutralization, reduced lactic acid production, and lowered CFU count (P < 0.05). Enamel treated with NACP adhesive demonstrated the best remineralization effectiveness with remineralization value of 52.29 ± 4.79% according to TMR. Better microhardness recovery of cross sections and ample mineral deposits were also observed in NACP group.
conclusionsThe NACP adhesive exhibited good performance in remineralizing initial enamel lesion with cariogenic biofilm. SIGNIFICANCE: The NACP adhesive is promising to be applied for the protection of bonding interface, prevention of secondary caries, and longevity prolonging of the restoration.
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Registered trials
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