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ArticleStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2021

Head and neck radiotherapy on the MR linac: a multicenter planning challenge amongst MRIdian platform users.

Madalyne Chamberlain, Jerome Krayenbuehl, Janita E van Timmeren, Lotte Wilke, Nicolaus Andratschke, Helena Garcia Schüler, Stephanie Tanadini-Lang, Matthias Guckenberger, Panagiotis Balermpas

Open access · hybridAbstract readMulticenter Study
In one paragraph

Article in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Madalyne ChamberlainDepartment of Radiation Oncology, University Hospital Zurich, Zurich, Switzerland. Madalyne.chamberlain@usz.ch.ORCID http://orcid.org/0000-0002-4300-1973
Jerome KrayenbuehlDepartment of Radiation Oncology, University Hospital Zurich, Zurich, Switzerland.
Janita E van TimmerenDepartment of Radiation Oncology, University Hospital Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-8166-6853
Lotte WilkeDepartment of Radiation Oncology, University Hospital Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-0702-2355
Nicolaus AndratschkeDepartment of Radiation Oncology, University Hospital Zurich, Zurich, Switzerland.
Helena Garcia SchülerDepartment of Radiation Oncology, University Hospital Zurich, Zurich, Switzerland.
Stephanie Tanadini-LangDepartment of Radiation Oncology, University Hospital Zurich, Zurich, Switzerland.
Matthias GuckenbergerDepartment of Radiation Oncology, University Hospital Zurich, Zurich, Switzerland.
Panagiotis BalermpasDepartment of Radiation Oncology, University Hospital Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0001-5261-6446
University Hospital of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePurpose of this study is to evaluate plan quality on the MRIdian (Viewray Inc., Oakwood Village, OH, USA) system for head and neck cancer (HNC) through comparison of planning approaches of several centers.

methodsA total of 14 planners using the MRIdian planning system participated in this treatment challenge, centrally organized by ViewRay, for one contoured case of oropharyngeal carcinoma with standard constraints for organs at risk (OAR). Homogeneity, conformity, sparing of OARs, and other parameters were evaluated according to The International Commission on Radiation Units and Measurements (ICRU) recommendations anonymously, and then compared between centers. Differences amongst centers were assessed by means of Wilcoxon test. Each plan had to fulfil hard constraints based on dose-volume histogram (DVH) parameters and delivery time. A plan quality metric (PQM) was evaluated. The PQM was defined as the sum of 16 submetrics characterizing different DVH goals.

resultsFor most dose parameters the median score of all centers was higher than the threshold that results in an ideal score. Six participants achieved the maximum number of points for the OAR dose parameters, and none had an unacceptable performance on any of the metrics. Each planner was able to achieve all the requirements except for one which exceeded delivery time. The number of segments correlated to improved PQM and inversely correlated to brainstem D

conclusionMagnetic Resonance Image (MRI) linac-based planning for HNC is already feasible with good quality. Generally, an increased number of segments and increasing planning experience are able to provide better results regarding planning quality without significantly prolonging overall treatment time.

Indexed as

Radiotherapy, Intensity-ModulatedHumansOrgans at RiskParticle AcceleratorsRadiotherapy DosageRadiotherapy Planning, Computer-AssistedLow field magnetic resonance imagingMR-adaptive treatment planningMR-guided radiation therapyStep-and-shoot IMRTTreatment plan comparison

Identifiers

PMID33891126
PMCPMC8604891
OpenAlexW3156644671

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.