Evidence map›Paper›PMID 33890863›Full record

ArticleJMIR formative research2021

A Brief Training Program to Support the Use of a Digital Pill System for Medication Adherence: Pilot Descriptive Study.

Peter R Chai, Maria J Bustamante, Georgia Goodman, Yassir Mohamed, Jesse Najarro, Matthew C Sullivan, Jose Castillo-Mancilla, Ryan P Coyle, Kenneth H Mayer, Rochelle K Rosen and 4 more

Open access · goldAbstract read
In one paragraph

Article in JMIR formative research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Real-World Implementation Challenges Associated with a Digital Pill System to Measure Adherence to HIV Pre-Exposure Prophylaxis from Two Studies of Men Who Have Sex With Men.Proceedings of the ... Annual Hawaii International Conference on System Sciences. Annual Hawaii International Conference on System Sciences · 2024
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Peter R ChaiDepartment of Emergency Medicine, Brigham and Women's Hospital, Boston, MA, United States.ORCID https://orcid.org/0000-0003-0955-4117
Maria J BustamanteThe Fenway Institute, Boston, MA, United States.ORCID https://orcid.org/0000-0002-6235-5363
Georgia GoodmanThe Fenway Institute, Boston, MA, United States.ORCID https://orcid.org/0000-0002-9404-4455
Yassir MohamedThe Fenway Institute, Boston, MA, United States.ORCID https://orcid.org/0000-0003-4629-4350
Jesse NajarroThe Fenway Institute, Boston, MA, United States.ORCID https://orcid.org/0000-0003-3741-228X
Matthew C SullivanThe Fenway Institute, Boston, MA, United States.ORCID https://orcid.org/0000-0002-2528-7787
Jose Castillo-MancillaDivision of Infectious Disease, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.ORCID https://orcid.org/0000-0003-1242-1745
Ryan P CoyleDivision of Infectious Disease, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.ORCID https://orcid.org/0000-0001-6472-7020
Kenneth H MayerThe Fenway Institute, Boston, MA, United States.ORCID https://orcid.org/0000-0001-7460-733X
Rochelle K RosenCenter for Behavioral and Preventive Medicine, The Miriam Hospital, Providence, RI, United States.ORCID https://orcid.org/0000-0003-1598-667X
Susan L BaumgartnereTectRx Inc, Gainesville, FL, United States.ORCID https://orcid.org/0000-0002-0679-8581
Pamela E AlperteTectRx Inc, Gainesville, FL, United States.ORCID https://orcid.org/0000-0002-7080-8932
Edward W BoyerDepartment of Emergency Medicine, Brigham and Women's Hospital, Boston, MA, United States.ORCID https://orcid.org/0000-0002-5884-0315
Conall O'CleirighThe Fenway Institute, Boston, MA, United States.ORCID https://orcid.org/0000-0002-5639-5043
Fenway Health · USMassachusetts General Hospital · USBrigham and Women's Hospital · USUniversity of Colorado Anschutz Medical Campus · USBeth Israel Deaconess Medical Center · USBrown University · US

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ARTHUR Y KIM · 2004 to 2026
$94.4M
New Pharmacologic Measures of ART Adherence and Exposure: Pathway to Clinical ImplementationR01AI145453 · NIAID · UNIVERSITY OF COLORADO DENVER · PI ANDERSON, PETER L. · 2019 to 2023
$3.7M
MyTPill: A Novel Strategy to Monitor Antiretroviral Adherence among HIV+ Prescription Opioid UsersR01DA047236 · NIDA · OHIO STATE UNIVERSITY · PI BOYER, EDWARD W, CARRICO, ADAM WAYNE · 2019 to 2022
$3.0M
Mentoring in Advanced mHealth Technologies and Machine Learning for HIV/Drug Abuse ResearchK24DA037109 · NIDA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BOYER, EDWARD W · 2014 to 2025
$1.9M
A novel robotic wastewater analysis system to quantify opioid exposure and treatment in residential communitiesR44DA051106 · NIDA · BIOBOT ANALYTICS, INC. · PI CHAI, PETER R, MATUS GARCIA, MARIANA G · 2020 to 2022
$1.5M
Development of Ingestible Biosensors to Enhance PrEP Adherence in Substance UsersK23DA044874 · NIDA · BRIGHAM AND WOMEN'S HOSPITAL · PI CHAI, PETER R · 2018 to 2022
$1.0M
NIDA National Early Warning System Network (iN3): An Innovative ApproachR56DA038366 · NIDA · WRIGHT STATE UNIVERSITY · PI BOYER, EDWARD W, CARLSON, ROBERT GEOFFREY · 2014 to 2014
$300k
NIAID NIH HHS P30 AI060354NIAID NIH HHS R01 AI145453NIDA NIH HHS K23 DA044874NIDA NIH HHS K24 DA037109NIDA NIH HHS R01 DA047236NIDA NIH HHS R44 DA051106NIDA NIH HHS R56 DA038366
6 · The paper itself

Abstract

backgroundDigital pill systems (DPSs), which comprise ingestible radiofrequency sensors integrated into a gelatin capsule that overencapsulates a medication, can directly measure ingestion events.

objectiveTeaching users to operate a DPS is vital to ensure the collection of actionable ingestion and adherence data. In this study, we aim to develop and pilot a training program, grounded in the Technology Acceptance Model, to instruct individuals on DPS operation.

methodsA two-part training program, comprising in-person and text message-based components, was used with HIV-negative men who have sex with men with nonalcohol substance use, who had enrolled in a 90-day pilot demonstration study using the DPS to measure adherence to pre-exposure prophylaxis. We assessed the number of responses to text check-ins, the number and types of episodes where technical support was requested, the resolutions of such issues, and engagement with the program over the study period. Participant feedback on the program was evaluated through qualitative user experience interviews.

resultsA total of 15 participants were enrolled in and completed the program. Seven technical challenges related to DPS operations were reported across 5 participants. Most commonly, participants requested support connecting the wearable Reader device with their smartphone, charging the Reader, and operating the mobile app. A total of 6 issues were resolved asynchronously or in real time via phone; 1 required in-person evaluation and resolution. Preliminary qualitative findings indicate that both the in-person and remote follow-up components of the training program were perceived as acceptable. Suggested improvements included repeated DPS refresher sessions at in-person follow-up visits and enhanced written materials for the independent resolution of technological issues.

conclusionsA brief two-part DPS training program, drawing from individuals' experiences and from the Technology Acceptance Model, can provide valuable insights for users. The program also identifies and addresses several areas of actual or potential challenges related to operating a DPS and allows for the resolution of such issues within the first week of DPS use.

Indexed as

digital pill systemHIV preventioningestible sensorsmobile phonePrEPtechnology training

Identifiers

PMID33890863
PMCPMC8105755
OpenAlexW3152954895

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.