Evidence map›Paper›PMID 33890812›Full record

ArticleCirculation research2021

Immunometabolic Endothelial Phenotypes: Integrating Inflammation and Glucose Metabolism.

Wusheng Xiao, William M Oldham, Carmen Priolo, Arvind K Pandey, Joseph Loscalzo

Open access · bronzeAbstract read
In one paragraph

Article in Circulation research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Excess glutamine rewires endothelial cell metabolism.Metabolomics : Official journal of the Metabolomic Society · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Wusheng XiaoDivision of Cardiovascular Medicine (W.X., A.K.P., J.L.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
William M OldhamDivision of Pulmonary and Critical Care Medicine, Department of Medicine (W.M.O., C.P.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Carmen PrioloDivision of Pulmonary and Critical Care Medicine, Department of Medicine (W.M.O., C.P.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Arvind K PandeyDivision of Cardiovascular Medicine (W.X., A.K.P., J.L.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Joseph LoscalzoDivision of Cardiovascular Medicine (W.X., A.K.P., J.L.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Brigham and Women's Hospital · US

Funding

Boston Biomedical Innovation CenterU54HL119145 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI GOLAN, DAVID E., LOSCALZO, JOSEPH · 2013 to 2021
$18.8M
TRANSLATIONAL PHARMACOLOGY COREP50GM107618 · NIGMS · HARVARD MEDICAL SCHOOL · PI SORGER, PETER KARL · 2014 to 2018
$10.8M
Center for Integrated Approaches to Undiagnosed DiseasesU01HG007690 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI LOSCALZO, JOSEPH · 2014 to 2022
$10.4M
GPx-3 and Peroxide Flux in the Endothelial CellR37HL061795 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LOSCALZO, JOSEPH · 2007 to 2016
$4.3M
L-2-Hydroxyglutarate and Metabolic Remodeling in HypoxiaR01HL155107 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Joseph Loscalzo · 2021 to 2026
$4.1M
Regulation of pulmonary vascular cell redox state by L-2-hydroxyglutarateK08HL128802 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI OLDHAM, WILLIAM MICHAEL · 2016 to 2020
$862k
NHGRI NIH HHS U01 HG007690NHLBI NIH HHS K08 HL128802NHLBI NIH HHS R01 HL155107NHLBI NIH HHS R37 HL061795NHLBI NIH HHS U54 HL119145NIGMS NIH HHS P50 GM107618
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

MetabolomeAnimalsCoculture TechniquesEndothelial CellsEnergy MetabolismGene Expression RegulationGlucoseGlycolysisHumansInflammationInflammation MediatorsKineticsLeukocyte RollingLeukocytesLipopolysaccharidesMaleGlucoseInflammation Mediatorslipopolysaccharide, Escherichia coli O111 B4LipopolysaccharidesTNF protein, humanTumor Necrosis Factor-alphaendothelial cellsglucoseglycolysisinflammationmitochondria

Identifiers

PMID33890812
PMCPMC8221540
OpenAlexW3153371298

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.