Evidence map›Paper›PMID 33890794›Full record

ArticleMolecular pharmaceutics2021

Niklas J Koehl, Laura J Henze, Harriet Bennett-Lenane, Waleed Faisal, Daniel J Price, René Holm, Martin Kuentz, Brendan T Griffin

Open access · hybridAbstract read
In one paragraph

Article in Molecular pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 6 countries.

Niklas J KoehlSchool of Pharmacy, University College Cork, College Road, T12 YN60 Cork, Ireland.ORCID 0000-0002-0565-9192
Laura J HenzeSchool of Pharmacy, University College Cork, College Road, T12 YN60 Cork, Ireland.
Harriet Bennett-LenaneSchool of Pharmacy, University College Cork, College Road, T12 YN60 Cork, Ireland.
Waleed FaisalSchool of Pharmacy, University College Cork, College Road, T12 YN60 Cork, Ireland.
Daniel J PriceMerck KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany.
René HolmDrug Product Development, Janssen Research and Development, Johnson & Johnson, Turnhoutseweg 30, 2340 Beerse, Belgium.
Martin KuentzInstitute of Pharma Technology, University of Applied Sciences and Arts Northwestern Switzerland, Hofackerstrasse 30, 4132 Muttenz, Switzerland.ORCID 0000-0003-2963-2645
Brendan T GriffinSchool of Pharmacy, University College Cork, College Road, T12 YN60 Cork, Ireland.ORCID 0000-0001-5433-8398
University College Cork · IEJanssen (Belgium) · BEFHNW University of Applied Sciences and Arts · CHGoethe University Frankfurt · DERoskilde University · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The concept of using precipitation inhibitors (PIs) to sustain supersaturation is well established for amorphous formulations but less in the case of lipid-based formulations (LBF). This study applied a systematic

Indexed as

Administration, OralAnimalsBiological AvailabilityBridged Bicyclo Compounds, HeterocyclicChemical PrecipitationChemistry, PharmaceuticalComputer SimulationDrug CompoundingDrug DevelopmentExcipientsLipidsMaleModels, AnimalModels, ChemicalSolubilitySulfonamidesBridged Bicyclo Compounds, HeterocyclicExcipientsLipidsSulfonamidesvenetoclaxlipid based formulationlipid suspensionpolymersprecipitation inhibitorSEDDSSMEDDSSNEDDSsupersaturating drug delivery systemssupersaturationsuper-SMEDDSsuper-SNEDDSvenetoclax

Identifiers

PMID33890794
PMCPMC8289286
OpenAlexW3155371837

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.