ReviewGenome biology and evolution2021
Evolutionary Perspectives on Germline-Restricted Chromosomes in Flies (Diptera).
Review in Genome biology and evolution, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- The mechanistic and evolutionary diversity of programmed DNA elimination.Nature reviews. Genetics · 2026Review
- Non-coding DNA dynamics and its roles as a physical barrier in genome safeguarding across early development and evolution.Heredity · 2026Review
- Single-Nucleus Transcriptome Analysis Provides New Insights Into B Chromosome Elimination in Sorghum.Plant biotechnology journal · 2026Article
- Sorghum embryos undergoing B chromosome elimination express B-variants of mitotic-related genes.Genome biology · 2025Article
- Distinct satellite DNA composition between core and germline restricted chromosomes in Bradysia (Sciara) coprophila.G3 (Bethesda, Md.) · 2025Article
- The Tree of Sex consortium: a global initiative for studying the evolution of reproduction in eukaryotes.Journal of evolutionary biology · 2025Article
- Biparental inheritance of germline-specific chromosomes in the sea lamprey and their roles in oocytes.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Why put all your eggs in one basket? Evolutionary perspectives on the origins of monogenic reproduction.Heredity · 2023Review
- Recent Evolution of a Maternally Acting Sex-Determining Supergene in a Fly with Single-Sex Broods.Molecular biology and evolution · 2023Article
- Biocatalytic potential ofiScience · 2023Article
- Parthenogenesis in dipterans: a genetic perspective.Proceedings. Biological sciences · 2023Review
- The nematode Oscheius tipulae as a genetic model for programmed DNA elimination.Current biology : CB · 2022Article
- Paternal genome elimination promotes altruism in viscous populations.Evolution; international journal of organic evolution · 2022Article
- Non-random chromosome segregation and chromosome eliminations in the fly Bradysia (Sciara).Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2022Review
- Mendelian nightmares: the germline-restricted chromosome of songbirds.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2022Review
- Gene-rich germline-restricted chromosomes in black-winged fungus gnats evolved through hybridization.PLoS biology · 2022Article
- Programmed DNA elimination: silencing genes and repetitive sequences in somatic cells.Biochemical Society transactions · 2021Review
- New Perspectives on the Evolution of Within-Individual Genome Variation and Germline/Soma Distinction.Genome biology and evolution · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In some eukaryotes, germline soma differentiation involves elimination of parts of the genome from somatic cells. The portions of the genome restricted to the germline often contain genes that play a role in development and function of the germline. Lineages with germline-restricted DNA are taxonomically diverse, and the size of the germline-restricted genome varies substantially. Unfortunately, few of these lineages have been studied in detail. As a result, we understand little about the general evolutionary forces that drive the origin and maintenance of germline-restricted DNA. One of the taxonomic groups where germline-restricted DNA has been poorly studied are the flies (Diptera). In three Dipteran families, Chironomidae, Cecidomyiidae, and Sciaridae, entire chromosomes are eliminated from somatic cells early in embryonic development. Germline-restricted chromosomes are thought to have evolved independently in the Dipteran families and their size, number, and transmission patterns vary between families. Although there is a wealth of cytological studies on these chromosomes in flies, almost no genomic studies have been undertaken. As a result, very little is known about how and why they evolved and what genes they encode. This review summarizes the literature on germline-restricted chromosomes in Diptera, discusses hypotheses for their origin and function, and compares germline-restricted DNA in Diptera to other eukaryotes. Finally, we discuss why Dipteran lineages represent a promising system for the study of germline-restricted chromosomes and propose future avenues of research on this topic.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.