Evidence map›Paper›PMID 33890542›Full record

ArticleAutophagy2021

HIV-1 Vpr protein impairs lysosome clearance causing SNCA/alpha-synuclein accumulation in neurons.

Maryline Santerre, Sterling P Arjona, Charles Ns Allen, Shannon Callen, Shilpa Buch, Bassel E Sawaya

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 45 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Maryline SanterreMolecular Studies of Neurodegenerative Diseases Lab, FELS Cancer Institute for Personalized Medicine and Department of Neurology Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Sterling P ArjonaMolecular Studies of Neurodegenerative Diseases Lab, FELS Cancer Institute for Personalized Medicine and Department of Neurology Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Charles Ns AllenMolecular Studies of Neurodegenerative Diseases Lab, FELS Cancer Institute for Personalized Medicine and Department of Neurology Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Shannon CallenDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0001-6241-3335
Shilpa BuchDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0002-3103-6685
Bassel E SawayaMolecular Studies of Neurodegenerative Diseases Lab, FELS Cancer Institute for Personalized Medicine and Department of Neurology Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Temple University · USUniversity of Nebraska Medical Center · US

Funding

PGC-1alpha and Reelin: new players in HAND progression.R01AG054411 · NIA · TEMPLE UNIV OF THE COMMONWEALTH · PI SAWAYA, BASSEL E · 2017 to 2021
$2.0M
NIA NIH HHS R01 AG054411
6 · The paper itself

Abstract

Despite the promising therapeutic effects of combinatory antiretroviral therapy (cART), 20% to 30% of HIV/AIDS patients living with long term infection still exhibit related cognitive and motor disorders. Clinical studies in HIV-infected patients revealed evidence of basal ganglia dysfunction, tremors, fine motor movement deficits, gait, balance, and increased risk of falls. Among older HIV

Indexed as

AIDS Dementia Complexalpha-SynucleinAnimalsAutophagosomesBlotting, WesternBrainFluorescent Antibody TechniqueHIV-1HumansLysosomesMacaca mulattaMiceMice, Inbred C57BLMicroscopy, Electron, TransmissionNeuronsvpr Gene Products, Human Immunodeficiency Virusalpha-SynucleinSNCA protein, humanvpr Gene Products, Human Immunodeficiency Virusvpr protein, Human immunodeficiency virus 1Alpha-synucleinautophagyHIV-1lysosomesmotor dysfunctionneuronsSnapin

Identifiers

PMID33890542
PMCPMC8354668
OpenAlexW3153107686

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.