Evidence map›Paper›PMID 33890515›Full record

Trial reportMultiple sclerosis (Houndmills, Basingstoke, England)2022

Effect of continuous positive airway pressure treatment of obstructive sleep apnea-hypopnea in multiple sclerosis: A randomized, double-blind, placebo-controlled trial (SAMS-PAP study).

Sulaiman Khadadah, R John Kimoff, Pierre Duquette, Vincent Jobin, Yves Lapierre, Andrea Benedetti, Fatema T Johara, Ann Robinson, Elaine Roger, Amit Bar-Or and 3 more

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Multiple sclerosis (Houndmills, Basingstoke, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01746342 (A Randomized, Controlled, Clinical Trial of Continuous Positive Airway Pressure Treatment of Obstructive Sleep Apnea-Hypopnea in Multiple Sclerosis), which is not on this map. Cited by 7 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 3 pooled it
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01746342 nacompletednot on this map

A Randomized, Controlled, Clinical Trial of Continuous Positive Airway Pressure Treatment of Obstructive Sleep Apnea-Hypopnea in Multiple Sclerosis

TypeinterventionalSponsorMcGill UniversityRan2013 to 2018Enrolled49ConditionsObstructive Sleep Apnea-hypopnea in Multiple Sclerosis PatientsArmsEffective continuous positive airway pressure (CPAP), Sham continuous positive airway pressure (CPAP)
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 3 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Sulaiman KhadadahRespiratory Division and Sleep Laboratory, McGill University Health Centre, Montreal, QC, Canada.
R John KimoffRespiratory Division and Sleep Laboratory, McGill University Health Centre, Montreal, QC, Canada.
Pierre DuquetteDepartment of Neuroscience, Centre Hospitalier de l'Université de Montréal, Université de Montréal, Montreal, QC, Canada.
Vincent JobinPulmonary Division, Department of Medicine, Centre Hospitalier de l'Université de Montréal, Université de Montréal, Montreal, QC, Canada.
Yves LapierreDepartment of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University Health Centre, McGill University, Montreal, QC, Canada.
Andrea BenedettiDepartment of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada.
Fatema T JoharaDepartment of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University Health Centre, McGill University, Montreal, QC, Canada.
Ann RobinsonDepartment of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University Health Centre, McGill University, Montreal, QC, Canada.
Elaine RogerDepartment of Neuroscience, Centre Hospitalier de l'Université de Montréal, Université de Montréal, Montreal, QC, Canada.
Amit Bar-OrCenter for Neuroinflammation and Experimental Therapeutics and Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
Gabriel LeonardDepartment of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University Health Centre, McGill University, Montreal, QC, Canada.
Marta KaminskaRespiratory Division and Respiratory Epidemiology and Clinical Research Unit, McGill University Health Centre, McGill University, Montreal, QC, Canada.
Daria A TrojanDepartment of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University Health Centre, McGill University, Montreal, QC, Canada.
McGill University Health Centre · CACentre Hospitalier de l’Université de Montréal · CAMcGill University · CAUniversity of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this study was to evaluate the effect of continuous positive airway pressure (CPAP) treatment on the Fatigue Severity Scale (FSS, preplanned primary outcome), another fatigue measure, sleep quality, somnolence, pain, disability, and quality of life in multiple sclerosis (MS) patients with obstructive sleep apnea-hypopnea (OSAH).

methodsIn a randomized, double-blind trial (NCT01746342), MS patients with fatigue, poor subjective sleep quality, and OSAH (apnea-hypopnea index of ⩾ 15 events per hour/sleep), but without severe OSAH (apnea-hypopnea index > 30, and 4% oxygen desaturation index > 15 events/hour or severe somnolence), were randomized to fixed CPAP or sham CPAP for 6 months. Outcome assessments were performed at 3 and 6 months.

resultsOf 49 randomized patients, 34 completed the protocol. Among completers, FSS did not improve with CPAP compared to sham at 6 months. FSS tended to improve (

conclusionIn non-severe OSAH patients, CPAP did not significantly improve the primary outcome of FSS change at 6 months. In secondary analyses, we found a trend to improved FSS, and a significant reduction in somnolence with CPAP at 3 months.

Indexed as

Multiple SclerosisSleep Apnea, ObstructiveContinuous Positive Airway PressureHumansQuality of LifeSleep QualityTreatment Outcomeclinical trialcontinuous positive airway pressurefatigueMultiple sclerosisobstructivesleepsleep apneasleepiness

Identifiers

PMID33890515
PMCPMC8688981
OpenAlexW3156047582

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.