Evidence map›Paper›PMID 33890177›Full record

ArticleActa diabetologica2021

Decreased expression of programmed death-1 on CD8

Yimei Shan, Yinghong Kong, Yan Zhou, Jingjing Guo, Qiyun Shi, Sicheng Li, Heming Guo, Yiting Huang, Sisi Ding, Cuiping Liu and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Acta diabetologica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Probiotics in reducing obesity by reconfiguring the gut microbiota.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Yimei ShanDepartment of Endocrinology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Yinghong KongDepartment of Endocrinology, Changshu No. 2 People's Hospital, Changshu, China.
Yan ZhouDepartment of Endocrinology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Jingjing GuoDepartment of Endocrinology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Qiyun ShiDepartment of Endocrinology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Sicheng LiDepartment of Endocrinology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Heming GuoDepartment of Endocrinology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Yiting HuangDepartment of Clinical Nutrition, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Sisi DingJiangsu Key Laboratory of Clinical Immunology, Soochow University, Suzhou, China.
Cuiping LiuJiangsu Key Laboratory of Clinical Immunology, Soochow University, Suzhou, China.
Lei CaoJiangsu Key Laboratory of Clinical Immunology, Soochow University, Suzhou, China.
Yun HuangDepartment of Endocrinology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Chen FangDepartment of Endocrinology, The Second Affiliated Hospital of Soochow University, Suzhou, China. afa9911@sina.com.ORCID http://orcid.org/0000-0003-4329-9471
Ji HuDepartment of Endocrinology, The Second Affiliated Hospital of Soochow University, Suzhou, China. huji@suda.edu.cn.
Soochow University · CNChangshu No.1 People's Hospital · CNNantong University · CN

Funding

National Natural Science Foundation of China 82070814Open project of the State Key Laboratory of Radiation Medicine and Radiation Protection jointly built by the Ministry and the province GZK1202025Scientific Research Project of Jiangsu Health Commission H2019043Scientific Research Project of Suzhou Health Commission SYS2019970Second Affiliated Hospital of Soochow University Science Foundation SDFEYQN1912Suzhou Science and Education Health Project kjxw2019015
6 · The paper itself

Abstract

aimsChronic inflammation of autoimmune diseases, including type 1 diabetes (T1D), is mainly mediated by memory T(Tm) cells, predominantly effector memory T (Tem) cells. The roles of the programmed death-1 (PD-1) receptor on lymphocytes have been well studied in tumor and other infection models. However, little is known about the relationship between the expression of PD-1 on CD8

methodsA total of 52 patients diagnosed with T1D and 39 gender-, age-, and ethnically matched health control individuals were enrolled in this study. Peripheral blood mononuclear cells from these individuals were isolated and analyzed by flow cytometry. We evaluated the frequencies of PD-1

resultsFrequencies of PD-1

conclusionsIt is the first report of the expression of PD-1 on CD8

Indexed as

Diabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1AnimalsCD8-Positive T-LymphocytesHumansLeukocytes, MononuclearMiceProgrammed Cell Death 1 ReceptorPDCD1 protein, humanPdcd1 protein, mouseProgrammed Cell Death 1 ReceptorCD8+ effector memory T cellsNOD micePD-1/PD-L1 pathwayProgrammed death-1Type 1 diabetes mellitus

Identifiers

PMID33890177
OpenAlexW3154170367

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.