Evidence map›Paper›PMID 33890163›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2021

Associations between religious and spiritual variables and neuroimmune activity in survivors of breast cancer: a feasibility study.

Jennifer M Hulett, Brick Johnstone, Jane M Armer, Chelsea Deroche, Rami Millspaugh, Joshua Millspaugh

Abstract read
PubMed Publisher
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Effect of mindfulness-based therapy on spiritual well-being in breast cancer patients: a randomized controlled study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Trial
  2. Observational
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jennifer M HulettSinclair School of Nursing, University of Missouri, Columbia, MO, 65211-6000, USA. hulettjm@missouri.edu.
Brick JohnstoneShepherd Center, 2020 Peachtree Road NW, Atlanta, GA, USA.
Jane M ArmerSinclair School of Nursing, University of Missouri, Columbia, MO, 65211-6000, USA.
Chelsea DerocheSinclair School of Nursing, University of Missouri, Columbia, MO, 65211-6000, USA.
Rami MillspaughWildlife Biology Program, Department of Ecosystem and Conservation Sciences, W.A. Franke College of Forestry and Conservation, University of Montana, Missoula, MT, USA.
Joshua MillspaughWildlife Biology Program, Department of Ecosystem and Conservation Sciences, W.A. Franke College of Forestry and Conservation, University of Montana, Missoula, MT, USA.

Funding

Interdisciplinary Training in Cancer, Caregiving and End-of-Life CareT32NR013456 · NINR · UNIVERSITY OF UTAH · PI ELLINGTON, LEE A, MOONEY, KATHLEEN H · 2013 to 2022
$3.4M
NINR NIH HHS T32NR013456
6 · The paper itself

Abstract

purposeChronic stress is associated with neuroimmune inflammation and adverse outcomes in breast cancer survivors. Some breast cancer survivors rely on religious and spiritual (R/S) variables to manage stress after breast cancer treatment. A spiritually based psychoneuroimmunological (PNI) model of health suggests that R/S variables influence neuroimmune activity; however, these associations are not well-established. A pilot study was conducted to assess the feasibility of studying associations between R/S variables and neuroimmune biomarkers in breast cancer survivors.

methodSalivary alpha-amylase (sAA) and interleukin-6 (IL-6) were sampled among women previously treated for breast cancer. The primary aim was to assess feasibility and acceptability of the sampling protocol. A secondary aim explored associations between sAA, IL-6, R/S variables, and health outcomes.

resultForty-one women completed the study. Biomarker sampling yielded 246 acceptable specimens used for analysis. SAA was detectable in 96% of specimens and IL-6 was detectable in 44% of specimens. The R/S variables with the strongest associations to sAA were spiritual self-rank (rs = .39; p < .05) and forgiveness (rs = .40; p < .05). The R/S variable with the strongest association to salivary IL-6 was positive congregational support (rs = .42; p < .05).

conclusionFeasibility and acceptability of the sampling protocol were confirmed. Reference ranges for sAA and IL-6 for female breast cancer survivors are presented. Results suggest that spiritual beliefs and religious practices are associated with neuroimmune activity, adding credence to a spiritually based PNI model of health. Findings lay the foundations for future R/S-based interventions to promote health and well-being in breast cancer survivors.

Indexed as

Breast NeoplasmsAdaptation, PsychologicalFeasibility StudiesFemaleHealth PromotionHumansPilot ProjectsSpiritualitySurvivorsBreast cancerInterleukin-6NeuroimmuneReligiousSalivary alpha-amylaseSpiritual

Identifiers

PMID33890163

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.