Evidence map›Paper›PMID 33890158›Full record

Trial reportEuropean journal of applied physiology2021

The effects of three types of exercise training on steroid hormones in physically inactive middle-aged adults: a randomized controlled trial.

Manuel Dote-Montero, Alejandro De-la-O, Lucas Jurado-Fasoli, Jonatan R Ruiz, Manuel J Castillo, Francisco J Amaro-Gahete

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of applied physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03334357 (Physical Fitness as Klotho Protein Stimulator; Antiaging Effects of New Training Methods), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03334357 nacompletednot on this map

Physical Fitness as Klotho Protein Stimulator; Antiaging Effects of New Training Methods (FIT-AGING).

TypeinterventionalSponsorManuel Castillo GarzónRan2016 to 2017Enrolled74ConditionsPhysical Activity, AgingArmsPAR, HIIT, WB-EMS
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Manuel Dote-MonteroPROmoting FITness and Health Through Physical Activity Research Group (PROFITH), Department of Physical Education and Sports, Faculty of Sports Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Camino de Alfacar s/n, 18071, Granada, Spain. manueldote@ugr.es.ORCID http://orcid.org/0000-0003-0715-8620
Alejandro De-la-OEFFECTS-262 Research Group, Department of Physiology, Faculty of Medicine, University of Granada, Avda. de la Investigación 11, 18016, Granada, Spain.ORCID http://orcid.org/0000-0002-0614-4545
Lucas Jurado-FasoliPROmoting FITness and Health Through Physical Activity Research Group (PROFITH), Department of Physical Education and Sports, Faculty of Sports Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Camino de Alfacar s/n, 18071, Granada, Spain.ORCID http://orcid.org/0000-0002-5254-1816
Jonatan R RuizPROmoting FITness and Health Through Physical Activity Research Group (PROFITH), Department of Physical Education and Sports, Faculty of Sports Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Camino de Alfacar s/n, 18071, Granada, Spain.ORCID http://orcid.org/0000-0002-7548-7138
Manuel J CastilloEFFECTS-262 Research Group, Department of Physiology, Faculty of Medicine, University of Granada, Avda. de la Investigación 11, 18016, Granada, Spain.ORCID http://orcid.org/0000-0002-1196-9488
Francisco J Amaro-GahetePROmoting FITness and Health Through Physical Activity Research Group (PROFITH), Department of Physical Education and Sports, Faculty of Sports Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Camino de Alfacar s/n, 18071, Granada, Spain.ORCID http://orcid.org/0000-0002-7207-9016
Universidad de Granada · ES

Funding

Ministerio de Ciencia, Innovación y Universidades FPU14/04172Ministerio de Ciencia, Innovación y Universidades FPU15/03960Ministerio de Ciencia, Innovación y Universidades FPU18/03357
6 · The paper itself

Abstract

purposePhysical inactivity and ageing are associated with imbalances in anabolic/catabolic steroid hormones, jeopardizing health. We investigated the effects of three types of training on plasma steroid hormone levels in physically inactive, middle-aged adults.

methodsA 12-week randomized controlled trial was performed with a parallel-group design. A total of 67 (36 women) middle-aged adults (45-65 years old) were randomly assigned to (1) no exercise (control), (2) concurrent training based on the international physical activity recommendations (PAR), (3) high-intensity interval training (HIIT), or (4) HIIT plus whole-body electromyostimulation (HIIT + EMS). The training volume in the PAR group was 150 min/week at 60-65% of the heart rate reserve for aerobic training and ~ 60 min/week at 40-50% of the one-repetition maximum for resistance training. The training volume in the HIIT and HIIT + EMS groups was 40-65 min/week at > 95% of the maximum oxygen uptake in long interval sessions, and > 120% of the maximum oxygen uptake in short interval sessions.

resultsCompared to the control group, dehydroepiandrosterone sulfate increased in the PAR, HIIT, and HIIT + EMS groups (~ 14%, ~ 14%, and ~ 20%, respectively; all P < 0.01). Cortisol decreased in the PAR, HIIT, and HIIT + EMS groups (~ - 17%, ~ - 10%, and ~ - 23%, respectively; all P ≤ 0.05). Testosterone increased in the HIIT and HIIT + EMS groups (~ 28%, and ~ 16%, respectively; all P ≤ 0.01). Free testosterone increased in the HIIT and HIIT + EMS groups (~ 30% and ~ 18% respectively; all P ≤ 0.01). No significant increase in sex hormone-binding globulin was observed (P = 0.869).

conclusionOur findings suggest that HIIT, with or without whole-body EMS, can significantly enhance steroid hormones status in previously physically inactive middle-aged adults. The PAR program led to slight improvements than the HIIT and HIIT + EMS groups despite the application of a higher training volume. CLINICAL TRIAL REGISTRY: NCT03334357 (ClinicalTrials.gov). November 7, 2017 retrospectively registered.

Indexed as

ExerciseSedentary BehaviorAgedDehydroepiandrosteroneFemaleHumansHydrocortisoneMaleMiddle AgedOxygen ConsumptionTestosteroneDehydroepiandrosteroneHydrocortisoneTestosteroneAerobic interval trainingAgeingAgingExerciseTime-efficient trainingTraining methodologies

Identifiers

PMID33890158
OpenAlexW3153607168

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.