ArticleEuropean journal of applied physiology2021
Cerebral blood flow velocity during simultaneous changes in mean arterial pressure and cardiac output in healthy volunteers.
Article in European journal of applied physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05131217 (Effects of Acute Exercise Intensity on Cerebral Blood Flow and Cognitive Function in Older Adults), which is not on this map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Acute Exercise Intensity on Cerebral Blood Flow and Cognitive Function in Older Adults
Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- Heart Meets Brain: Insights into Neurocardiac Pathophysiology.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Review
- Pressure-targeted neurocritical care at the bedside: the emerging role of transcranial doppler.Critical care (London, England) · 2026Review
- In Reply to: Comment on "Effect of intraoperative position on the zero flow pressure of the cerebral circulation under propofol anesthesia: a prospective observational study".Journal of anesthesia · 2026Article
- Association between intraoperative hypotension and postoperative ICU delirium: a retrospective observational study.Journal of anesthesia · 2026Observational
- Association between electrolyte disturbance score and 30-day severe disturbance of consciousness and in-hospital mortality in intensive care unit patients with intracerebral hemorrhage: A retrospective observational cohort study.The Journal of international medical research · 2026Observational
- Recent advances in postoperative delirium in elderly patients: pathophysiological mechanisms, risk prediction, and therapeutic strategies.Frontiers in neuroscience · 2026Review
- Correlation between hemodynamic characterizations of cervical arteries and changes in cerebral microcirculation under dobutamine stress: a self-controlled study.BMC medical imaging · 2025Article
- Clinical efficacy of neurofacilitation technology combined with rehabilitation training based on cerebral blood flow velocity and cerebral metabolism in children with cerebral palsy.Frontiers in medicine · 2025Article
- The value of multimodal MRI in the clinical grading of acute cerebral infarction.Frontiers in neuroscience · 2025Article
- Ingesting carbonated water post-exercise in the heat transiently ameliorates hypotension and enhances mood state.Experimental physiology · 2024Article
- Unraveling diurnal and technical variability in cerebral hemodynamics from neurovascular 4D-Flow MRI.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Article
- Hemodynamic effects of supplemental oxygen versus air in simulated blood loss in healthy volunteers: a randomized, controlled, double-blind, crossover trial.Intensive care medicine experimental · 2023Article
- Article
- Effects of Auricular Point Acupressure with Lifestyle Interventions on Cerebrovascular Function among Adults with High Stroke Risk: A Randomized Controlled Study.Evidence-based complementary and alternative medicine : eCAM · 2023Article
- Article
- Closed-Loop Identification of Baroreflex Properties in the Frequency Domain.Frontiers in neuroscience · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCerebral blood flow (CBF) needs to be precisely controlled to maintain brain functions. While previously believed to be autoregulated and near constant over a wide blood pressure range, CBF is now understood as more pressure passive. However, there are still questions regarding the integrated nature of CBF regulation and more specifically the role of cardiac output. Our aim was, therefore, to explore the effects of MAP and cardiac output on CBF in a combined model of reduced preload and increased afterload.
method16 healthy volunteers were exposed to combinations of different levels of simultaneous lower body negative pressure and isometric hand grip. We measured blood velocity in the middle cerebral artery (MCAV) and internal carotid artery (ICAV) by Doppler ultrasound, and cerebral oxygen saturation (ScO
resultBoth MAP and cardiac output had independent effects on MCAV, ICAV and ScO
conclusionThe present study indicates that during reductions in cardiac output, both MAP and cardiac output have independent effects on CBF.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.