ArticleFacts, views & vision in ObGyn2021
Prognosis in fertilisation rate and outcome in IVF cycles in patients with and without endometriosis: a population-based comparative cohort study with controls.
Article in Facts, views & vision in ObGyn, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Endometriosis as a risk factor: impact on IVF outcomes and reproductive parameters: a systematic review and meta-analysis.Archives of gynecology and obstetrics · 2025Pooled it
- In Vivo Shadows and In Vitro Light: The Early Embryological Journey Amid Endometriosis.Biology · 2025Review
- Comparison of success rates in early stages of in vitro fertilization (IVF) in women with and without endometriosis.Narra J · 2024Article
- Endometriosis and In Vitro Fertilization.Medicina (Kaunas, Lithuania) · 2024Review
- What is the impact of endometriosis and the AFS stage on cumulative pregnancy rates in IVF programs?Reproductive health · 2024Article
- Endometriosis, Oocyte, and Embryo Quality.Journal of clinical medicine · 2023Review
- Comparison of in vitro maturation and in vitro fertilization for polycystic ovary syndrome patients: a systematic review and meta-analysis.Annals of translational medicine · 2021Article
- Investigating Unilateral Ovarian Endometrioma's Effect on Ova and Embryo Quality in 409 Infertile Endometriotic Patients.Reproductive medicine and biologyArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSubfertility occurs in 30-40% of endometriosis patients. Regarding the fertilisation rate with in vitro fertilisation (IVF) and endometriosis, conflicting data has been published. This study aimed to compare endometriosis patients to non-endometriosis cycles assessing fertilisation rates in IVF.
methodsA population-based cohort study was conducted at the Leiden University Medical Center. IVF cycles of endometriosis patients and controls (unexplained infertility and tubal pathology) were analysed. The main outcome measurement was fertilisation rate.
results503 IVF cycles in total, 191 in the endometriosis group and 312 in the control. The mean fertilisation rate after IVF did not differ between both groups, 64.1%±25.5 versus 63.9%±24.8 (p=0.95) respectively, independent of age and r-ASRM classification. The median number of retrieved oocytes was lower in the endometriosis group (7.0 versus 8.0 respectively, p=0.19) and showed a significant difference when corrected for age (p=0.02). When divided into age groups, the statistical effect was only seen in the group of ≤ 35 years (p=0.04). In the age group ≤35, the endometriosis group also showed significantly more surgery on the internal reproductive organs compared to the control group (p<0.001). All other outcomes did not show significant differences.
conclusionSimilar fertilisation rates were found in endometriosis IVF cycles compared to controls. The oocyte retrieval was lower in the endometriosis group, however this effect was only significant in the age group ≤ 35 years. All other secondary outcomes did not show significant differences. In general, endometriosis patients with an IVF indication can be counselled positively regarding the chances of becoming pregnant, and do not need a different IVF approach.
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