Evidence map›Paper›PMID 33889521›Full record

ArticleTranslational lung cancer research2021

Isochorismatase domain-containing protein 1 (ISOC1) participates in DNA damage repair and inflammation-related pathways to promote lung cancer development.

Jinghan Shi, Fujun Yang, Nanfeng Zhou, Yan Jiang, Yanfeng Zhao, Junjie Zhu, Arsela Prelaj, Jyoti Malhotra, Nicola Normanno, Elisa Danese and 4 more

Open access · diamondAbstract read
In one paragraph

Article in Translational lung cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Exploring potential biomarkers of diffuse large B-cell lymphoma through multi-dimensional data.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  2. A brief history of the human liver peroxisome.Histochemistry and cell biology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 4 countries.

Jinghan ShiDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Fujun YangDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Nanfeng ZhouDepartment of Radiation Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Yan JiangDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Yanfeng ZhaoDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Junjie ZhuDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Arsela PrelajMedical Oncology Department, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
Jyoti MalhotraRutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Nicola NormannoCell Biology and Biotherapy Unit, Istituto Nazionale Tumori-IRCCS-"Fondazione G. Pascale", Naples, Italy.
Elisa DaneseSection of Clinical Biochemistry, University of Verona, Verona, Italy.
Andrés F CardonaFoundation for Clinical and Applied Cancer Research-FICMAC/Clinical and Translational Oncology Group, Clínica del Country/Molecular Oncology and Biology Systems Research Group (Fox-G), El Bosque University, Bogotá, Colombia.
Xuan HongDepartment of Thoracic Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Gening JiangDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Xiao SongDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Shanghai Pulmonary Hospital · CNTongji University · CNIstituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · ITPolitecnico di Milano · ITRutgers, The State University of New Jersey · USShanghai East Hospital · CNUniversidad El Bosque · COUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe advent of novel molecular targets has dramatically changed the treatment landscape of lung cancer in recent years. Isochorismatase domain-containing protein 1 (

methodsThe expression levels and prognostic significance of

resultsOur results found that

conclusionsWe demonstrated that

Indexed as

DNA damage repairinflammationIsochorismatase domain-containing protein 1 (ISOC1)lung cancermiR-4633

Identifiers

PMID33889521
PMCPMC8044495
OpenAlexW3145720896

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.