ArticlePeerJ2021
Optimal extraction, purification and antioxidant activity of total flavonoids from endophytic fungi of
Article in PeerJ, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Green Synthesis and Bioactivity Evaluation of Silver Nanoparticles from Stevia rebaudiana and the Endophyte Aspergillus versicolor.Current microbiology · 2026Article
- Endophyte-mediated biosynthesis of biogenic nanoparticles: mechanisms and biomedical applications.Archives of microbiology · 2026Review
- Flavonoids: biological activities, nutritional and immunological aspects, therapeutic potential, food applications, and human health benefits-A comprehensive review.Frontiers in nutrition · 2026Review
- Chemical Profiling and Antibacterial, Anti-Biofilm, and Antioxidant Activities of EndophyticJournal of microbiology and biotechnology · 2025Article
- Extraction and purification of total flavonoids from Zanthoxylum planispinum Var. Dintanensis leaves and effect of altitude on total flavonoids content.Scientific reports · 2025Article
- Advances in Flavonoid Research: Sources, Biological Activities, and Developmental Prospectives.Current issues in molecular biology · 2024Review
- Antifungal metabolites of biocontrol stain LB-1 and their inhibition mechanism againstFrontiers in microbiology · 2024Article
- Multicolor Hair Dyeing with Biocompatible Dark Polyphenol Complex-Integrated Shampoo with Reactive Oxygen Species Scavenging Activity.Biomimetics (Basel, Switzerland) · 2023Article
- Bioactive compounds and biomedical applications of endophytic fungi: a recent review.Microbial cell factories · 2023Review
- Extraction and purification of antioxidative flavonoids fromFrontiers in bioengineering and biotechnology · 2022Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFlavonoids are widely used in the market because of their antibacterial, antiviral, and antioxidant activities. But the production speed of flavonoids is limited by the growth of plants. CBL9 (
methodsIn this study, we isolated total flavonoids from endophytic fungus CBL9 of
resultsIt was found that the best parameters were 25 °C pH 2.80, 1.85 h, and the adsorption ratio reached (64.14 ± 0.04)%. A total of 60% ethanol was the best elution solvent. The elution ratio of total flavonoid reached to (81.54 ± 0.03)%, and the purity was 7.13%, which was increased by 14.55 times compared with the original fermentation broth. Moreover its purity could rise to 13.69% after precipitated by ethanol, which is very close to 14.10% prepared by ethyl acetate extraction. In the antioxidant research, the clearance ratio of L9F-M on DPPH, ABTS, •OH, •O
conclusionThe result indicated using macroporous resin in the extraction of total flavonoid from endophytic fungus is better than organic solvents with higher extraction ratio, safety and lower cost. In vitro testing indicated that the flavonoid extracted by macroporous resin have good antioxidant activity, providing more evidence for the production of flavonoid by biological fermentation method.
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