Evidence map›Paper›PMID 33889382›Full record

ArticleJournal of tissue engineering

Pro-angiogenic and osteogenic composite scaffolds of fibrin, alginate and calcium phosphate for bone tissue engineering.

Nupur Kohli, Vaibhav Sharma, Alodia Orera, Prasad Sawadkar, Nazanin Owji, Oliver G Frost, Russell J Bailey, Martyn Snow, Jonathan C Knowles, Gordon W Blunn and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of tissue engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

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  5. Pharmaceuticals (Basel, Switzerland) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nupur KohliRegenerative Biomaterials Group, The RAFT Institute & The Griffin Institute, Northwick Park & Saint Mark's Hospital, London, UK.
Vaibhav SharmaRegenerative Biomaterials Group, The RAFT Institute & The Griffin Institute, Northwick Park & Saint Mark's Hospital, London, UK.
Alodia OreraInstituto de Nanociencia y Materiales de Aragón (INMA), CSIC-Universidad de Zaragoza, Zaragoza, Spain.
Prasad SawadkarRegenerative Biomaterials Group, The RAFT Institute & The Griffin Institute, Northwick Park & Saint Mark's Hospital, London, UK.ORCID https://orcid.org/0000-0003-2956-1592
Nazanin OwjiDivision of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, University College London, London, UK.
Oliver G FrostRegenerative Biomaterials Group, The RAFT Institute & The Griffin Institute, Northwick Park & Saint Mark's Hospital, London, UK.
Russell J BaileyThe NanoVision Centre, School of Engineering and Materials Science, Queen Mary University of London, London, UK.
Martyn SnowRoyal Orthopaedic Hospital NHS Foundation Trust, Birmingham, UK.
Jonathan C KnowlesDivision of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, University College London, London, UK.ORCID https://orcid.org/0000-0003-3917-3446
Gordon W BlunnSchool of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, UK.
Elena García-GaretaRegenerative Biomaterials Group, The RAFT Institute & The Griffin Institute, Northwick Park & Saint Mark's Hospital, London, UK.ORCID https://orcid.org/0000-0001-7062-9099

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Due to the limitations of bone autografts, we aimed to develop new composite biomaterials with pro-angiogenic and osteogenic properties to be used as scaffolds in bone tissue engineering applications. We used a porous, cross-linked and slowly biodegradable fibrin/alginate scaffold originally developed in our laboratory for wound healing, throughout which deposits of calcium phosphate (CaP) were evenly incorporated using an established biomimetic method. Material characterisation revealed the porous nature and confirmed the deposition of CaP precursor phases throughout the scaffolds. MC3T3-E1 cells adhered to the scaffolds, proliferated, migrated and differentiated down the osteogenic pathway during the culture period. Chick chorioallantoic membrane (CAM) assay results showed that the scaffolds were pro-angiogenic and biocompatible. The work presented here gave useful insights into the potential of these pro-angiogenic and osteogenic scaffolds for bone tissue engineering and merits further research in a pre-clinical model prior to its clinical translation.

Indexed as

angiogenicBone tissue engineeringcalcium phosphatefibrinosteogenic

Identifiers

PMID33889382
PMCPMC8040555

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.