Evidence map›Paper›PMID 33889356›Full record

ReviewIranian journal of microbiology2021

Laboratory diagnosis of COVID-19: current status and challenges.

Bijina J Mathew, Ashish Kumar Vyas, Prashant Khare, Sudheer Gupta, Ram Kumar Nema, Shashwati Nema, Sudipti Gupta, Shivendra K Chaurasiya, Debasis Biswas, Anirudh K Singh

Abstract readReview
In one paragraph

Review in Iranian journal of microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bijina J MathewDepartment of Microbiology, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.
Ashish Kumar VyasDepartment of Microbiology, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.
Prashant KhareDepartment of Microbiology, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.
Sudheer GuptaRegional Virology Laboratory, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.
Ram Kumar NemaRegional Virology Laboratory, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.
Shashwati NemaDepartment of Microbiology, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.
Sudipti GuptaCenter for Clinical and Translational Medicine, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA.
Shivendra K ChaurasiyaDepartment of Biological Science and Engineering, Maulana Azad National Institute of Technology, Bhopal, Madhya Pradesh, India.
Debasis BiswasDepartment of Microbiology, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.
Anirudh K SinghDepartment of Microbiology, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The magnitude and pace of global affliction caused by Coronavirus Disease-19 (COVID-19) is unprecedented in the recent past. From starting in a busy seafood market in the Chinese city of Wuhan, the virus has spread across the globe in less than a year, infecting over 76 million people and causing death of close to 1.7 million individuals worldwide. As no specific antiviral treatment is currently available, the major strategy in containing the pandemic is focused on early diagnosis and prompt isolation of the infected individuals. Several diagnostic modalities have emerged within a relatively short period, which can be broadly classified into molecular and immunological assays. While the former category is centered around real-time PCR, which is currently considered the gold standard of diagnosis, the latter aims to detect viral antigens or antibodies specific to the viral antigens and is yet to be recommended as a stand-alone diagnostic tool. This review aims to provide an update on the different diagnostic modalities that are currently being used in diagnostic laboratories across the world as well as the upcoming methods and challenges associated with each of them. In a rapidly evolving diagnostic landscape with several testing platforms going through various phases of development and/or regulatory clearance, it is prudent that the clinical community familiarizes itself with the nuances of different testing modalities currently being employed for this condition.

Indexed as

CoronavirusCOVID-19COVID-19 nucleic acid testingDiagnosisEnzyme-linked immunosorbent assaySARS-CoV-2

Identifiers

PMID33889356
PMCPMC8043833

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.