ReviewWorld journal of diabetes2021
Diagnosis, treatment and prevention of type 2 diabetes mellitus in children and adolescents.
Review in World journal of diabetes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Depression comorbidity in children and adolescents with type 2 diabetes mellitus: a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Comparative Efficacy, Safety, and Cost-Utility of DPP-4 Inhibitors and Metformin Combination Therapy in Type 2 Diabetes: A Systematic Review of Real-World Clinical and Economic Outcomes.Journal of diabetes research · 2026Pooled it
- Efficacy and Safety of SGLT2 Inhibitors in Pediatric Patients and Young Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Pediatric diabetes · 2024Pooled it
- Review
- Emerging phenotype: Maturity-onset diabetes of the young type 5 (MODY-5) - mechanisms, clinical spectrum, and unmet needs.Diabetology & metabolic syndrome · 2025Review
- Transparency and Validity of Artificial Intelligence Applications in Pediatric Diabetes: A Systematic Review.Cureus · 2025Review
- Risk Factors for the Development of Early Onset Diabetes in the Population of Sindh Province, Pakistan.Biomedicines · 2025Article
- Emerging risk factors for heart failure in younger populations: A growing public health concern.World journal of cardiology · 2025Review
- The Regulatory Effect of Vitamin D on Pancreatic Beta Cell Secretion in Patients with Type 2 Diabetes.Current medicinal chemistry · 2025Review
- Pilot Study: Improving Glycemic Control Among Children and Adolescents With Obesity and Prediabetes With Real-Time Feedback Via Continuous Glucose Monitoring.Diabetes spectrum : a publication of the American Diabetes Association · 2025Article
- Global, regional, and national trends and burden of diabetes mellitus type 2 among youth from 1990 to 2021: an analysis from the global burden of disease study 2021.Frontiers in endocrinology · 2025Article
- Unraveling the complex relationship between night shift work and diabetes: exploring mechanisms and potential interventions.Frontiers in public health · 2025Review
- Are Trends in Economic Modeling of Pediatric Diabetes Mellitus up to Date with the Clinical Practice Guidelines and the Latest Scientific Findings?Journal of health economics and outcomes research · 2025Article
- Current Perspectives for Treating Adolescents with Obesity and Type 2 Diabetes: A Review.Nutrients · 2024Review
- Monogenic Defects of Beta Cell Function: From Clinical Suspicion to Genetic Diagnosis and Management of Rare Types of Diabetes.International journal of molecular sciences · 2024Review
- Endogenous electric field coupling Mxene sponge for diabetic wound management: haemostatic, antibacterial, and healing.Journal of nanobiotechnology · 2024Article
- Exosomal miRNAs and isomiRs: potential biomarkers for type 2 diabetes mellitus.Precision clinical medicine · 2024Review
- Fetal femur length and risk of diabetes in adolescence: a prospective cohort study.Tropical medicine and health · 2024Article
- Challenges in Type 2 Diabetes Prevention among Senior High School Students: A Qualitative Study.International journal of community based nursing and midwifery · 2024Article
- Wolfram Syndrome Type I Case Report and Review-Focus on Early Diagnosis and Genetic Variants.Medicina (Kaunas, Lithuania) · 2024Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the last two decades, there have been several reports of an increasing incidence of type 2 diabetes mellitus (T2DM) in children and adolescents, especially among those belonging to minority ethnic groups. This trend, which parallels the increases in prevalence and degree of pediatric obesity, has caused great concern, even though T2DM remains a relatively rare disease in children. Youth T2DM differs not only from type 1 diabetes in children, from which it is sometimes difficult to differentiate, but also from T2DM in adults, since it appears to be an aggressive disease with rapidly progressive β-cell decline, high treatment failure rate, and accelerated development of complications. Despite the recent research, many aspects of youth T2DM still remain unknown, regarding both its pathophysiology and risk factor contribution, and its optimal management and prevention. Current management approaches include lifestyle changes, such as improved diet and increased physical activity, together with pharmacological interventions, including metformin, insulin, and the recently approved glucagon-like peptide-1 analog liraglutide. What is more important for everyone to realize though, from patients, families and physicians to schools, health services and policy-makers alike, is that T2DM is a largely preventable disease that will be addressed effectively only if its major contributor (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.