Evidence map›Paper›PMID 33889182›Full record

ArticleThe journal of venomous animals and toxins including tropical diseases2021

Reverse vaccinology and subtractive genomics approaches for identifying common therapeutics against

Arun Kumar Jaiswal, Sandeep Tiwari, Syed Babar Jamal, Letícia de Castro Oliveira, Helioswilton Sales-Campos, Leonardo Eurípedes Andrade-Silva, Carlo Jose Freire Oliveira, Preetam Ghosh, Debmalya Barh, Vasco Azevedo and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of venomous animals and toxins including tropical diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. A review of nutrition in neuropathic pain of leprosy.Therapeutic advances in infectious disease
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 4 countries.

Arun Kumar JaiswalGraduate Program in Bioinformatics, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.ORCID 0000-0002-0558-483X
Sandeep TiwariGraduate Program in Bioinformatics, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.ORCID 0000-0002-8554-1660
Syed Babar JamalDepartment of Biological Sciences, National University of Medical Sciences, Rawalpindi, Punjab, Pakistan.ORCID 0000-0001-6916-7376
Letícia de Castro OliveiraGraduate Program in Bioinformatics, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.ORCID 0000-0002-2036-4456
Helioswilton Sales-CamposDepartment of Immunology, Microbiology and Parasitology, Institute of Biological Sciences and Natural Sciences, Federal University of Triângulo Mineiro (UFTM), Uberaba, MG, Brazil.ORCID 0000-0003-3252-2834
Leonardo Eurípedes Andrade-SilvaInfectious Disease Department, Institute of Health Sciences, Federal University of Triângulo Mineiro (UFTM), Uberaba, MG, Brazil.ORCID 0000-0002-0485-229X
Carlo Jose Freire OliveiraDepartment of Immunology, Microbiology and Parasitology, Institute of Biological Sciences and Natural Sciences, Federal University of Triângulo Mineiro (UFTM), Uberaba, MG, Brazil.ORCID 0000-0003-2211-7333
Preetam GhoshDepartment of Computer Science, Virginia Commonwealth University, Richmond, VA, USA.ORCID 0000-0003-3880-5886
Debmalya BarhCentre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, West Bengal, India.ORCID 0000-0002-2557-7768
Vasco AzevedoGraduate Program in Bioinformatics, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.ORCID 0000-0002-4775-2280
Siomar C SoaresDepartment of Immunology, Microbiology and Parasitology, Institute of Biological Sciences and Natural Sciences, Federal University of Triângulo Mineiro (UFTM), Uberaba, MG, Brazil.ORCID 0000-0001-7299-3724
Virmondes Rodrigues RodriguesDepartment of Immunology, Microbiology and Parasitology, Institute of Biological Sciences and Natural Sciences, Federal University of Triângulo Mineiro (UFTM), Uberaba, MG, Brazil.ORCID 0000-0001-8706-4223
Marcos Vinicius da SilvaDepartment of Immunology, Microbiology and Parasitology, Institute of Biological Sciences and Natural Sciences, Federal University of Triângulo Mineiro (UFTM), Uberaba, MG, Brazil.ORCID 0000-0002-2966-7621
Universidade Federal do Triângulo Mineiro · BRInstitute of Bioinformatics and Applied Biotechnology · INNational University of Medical Sciences · PKVirginia Commonwealth University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background

methodsIn this study, our contribution includes the prediction of vaccine targets and new putative drugs against leprosy, using reverse vaccinology and subtractive genomics. Six strains of

resultsAs a result, we identified 12 common putative antigenic proteins as vaccine targets and three common drug targets against

conclusionsThe bis-naphthoquinone compound Diospyrin (CID 308140) obtained from indigenous plant

Indexed as

Drug target identificationLeprosyMycobacterium lepraeMycobacterium lepromatosisVaccine targets

Identifiers

PMID33889182
PMCPMC8040911
OpenAlexW3156988848

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.