Evidence map›Paper›PMID 33889151›Full record

ArticleFrontiers in immunology2021

Elevated Numbers of HIV-Specific Poly-Functional CD8

Sivasankaran Munusamy Ponnan, Kannan Thiruvengadam, Sujitha Kathirvel, Janani Shankar, Akshaya Rajaraman, Manikannan Mathaiyan, Thongadi Ramesh Dinesha, Selvamuthu Poongulali, Shanmugam Saravanan, Kailapuri Gangatharan Murugavel and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

  1. Trial
  2. CD8Cell reports. Medicine · 2026
    Review
  3. Review
  4. Article
  5. An angel or a devil? Current view on the role of CD8Journal of translational medicine · 2024
    Review
  6. Memory stem CD8Frontiers in cellular and infection microbiology · 2024
    Review
  7. Can T Cells Abort SARS-CoV-2 and Other Viral Infections?International journal of molecular sciences · 2023
    Review
  8. Article
  9. Article
  10. T cell immunity to SARS-CoV-2.Seminars in immunology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 3 countries.

Sivasankaran Munusamy PonnanNational Institute for Research in Tuberculosis (Indian Council of Medical Research), Chennai, India.
Kannan ThiruvengadamNational Institute for Research in Tuberculosis (Indian Council of Medical Research), Chennai, India.
Sujitha KathirvelNational Institute for Research in Tuberculosis (Indian Council of Medical Research), Chennai, India.
Janani ShankarNational Institute for Research in Tuberculosis (Indian Council of Medical Research), Chennai, India.
Akshaya RajaramanNational Institute for Research in Tuberculosis (Indian Council of Medical Research), Chennai, India.
Manikannan MathaiyanNational Institute for Research in Tuberculosis (Indian Council of Medical Research), Chennai, India.
Thongadi Ramesh DineshaY. R. Gaitonde (YRG) Center for AIDS Research and Education, Chennai, India.
Selvamuthu PoongulaliChennai Antiviral Research and Treatment Centre and Clinical Research Site (CART CRS), Infectious Diseases Medical Center, Voluntary Health Services (VHS), Chennai, India.
Shanmugam SaravananY. R. Gaitonde (YRG) Center for AIDS Research and Education, Chennai, India.
Kailapuri Gangatharan MurugavelY. R. Gaitonde (YRG) Center for AIDS Research and Education, Chennai, India.
Soumya SwaminathanNational Institute for Research in Tuberculosis (Indian Council of Medical Research), Chennai, India.
Srikanth Prasad TripathyNational Institute for Research in Tuberculosis (Indian Council of Medical Research), Chennai, India.
Ujjwal NeogiDivision of Clinical Microbiology, Karolinska Institute, Stockholm, Sweden.
Vijayakumar VeluDivision of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States.
Luke Elizabeth HannaNational Institute for Research in Tuberculosis (Indian Council of Medical Research), Chennai, India.
National Institute of Research in Tuberculosis · INIndian Council of Medical Research · INYR Gaitonde Centre for AIDS Research and Education · INEmory University · USKarolinska Institutet · SEVoluntary Health Services Hospital · IN

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
YNPRC NHP CLINICAL MEDICINE RESIDENCY PROGRAM - SUPPLEMENTP51RR000165 · NCRR · EMORY UNIVERSITY · PI RENGARAJAN, JYOTHI · 1985 to 2011
$114.0M
Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0M
Combined cytokine therapy for sustained HIV remissionR01AI148377 · NIAID · EMORY UNIVERSITY · PI AMARA, RAMA RAO, VELU, VIJAYAKUMAR · 2020 to 2024
$4.6M
Immunologic changes associated with three progestin-based contraceptives: characterizing immune profiles over one year and identifying factors that may alter HIV riskR01HD095741 · NICHD · EMORY UNIVERSITY · PI HADDAD, LISA BLAKE, SMITH, ALICIA K · 2018 to 2022
$3.8M
Pilot Projects CoreP30NR016579 · NINR · UNIVERSITY OF MARYLAND BALTIMORE · PI DORSEY, SUSAN G, RENN, CYNTHIA L · 2016 to 2020
$2.7M
NCRR NIH HHS P51 RR000165NIAID NIH HHS P30 AI050409NIAID NIH HHS R01 AI148377NICHD NIH HHS R01 HD095741NIH HHS P51 OD011132NINR NIH HHS P30 NR016579
6 · The paper itself

Abstract

HIV-specific CD8

Indexed as

AdultAntigens, ViralCD8-Positive T-LymphocytesCell CountCell MovementFemaleGerminal CenterHIV-1HIV InfectionsHIV SeronegativityHumansMalePhenotypeStem CellsYoung AdultAntigens, ViralARTCTLCXCR5+ CD8+HESNHIVTSCM cells

Identifiers

PMID33889151
PMCPMC8056154
OpenAlexW3138982813

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.