Evidence map›Paper›PMID 33889147›Full record

ReviewFrontiers in microbiology2021

Biology of Polyomavirus miRNA.

Wei Zou, Michael J Imperiale

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Viral miRNA regulation of host gene expression.Seminars in cell & developmental biology · 2023
    Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. miRNA in Molecular Diagnostics.Bioengineering (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Wei ZouDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, United States.
Michael J ImperialeDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, United States.
University of Michigan–Ann Arbor · US

Funding

Parameters Governing Kidney Cell Infection with BKVR01AI060584 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI IMPERIALE, MICHAEL J. · 2004 to 2020
$4.8M
Cellular Targets of the BKPyV miRNAR21AI147155 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI IMPERIALE, MICHAEL J. · 2019 to 2020
$429k
NIAID NIH HHS R01 AI060584NIAID NIH HHS R21 AI147155
6 · The paper itself

Abstract

Polyomaviruses are a family of non-enveloped DNA viruses with wide host ranges. Human polyomaviruses typically cause asymptomatic infection and establish persistence but can be reactivated under certain conditions and cause severe diseases. Most well studied polyomaviruses encode a viral miRNA that regulates viral replication and pathogenesis by targeting both viral early genes and host genes. In this review, we summarize the current knowledge of polyomavirus miRNAs involved in virus infection. We review in detail the regulation of polyomavirus miRNA expression, as well as the role polyomavirus miRNAs play in viral pathogenesis by controlling both host and viral gene expression. An overview of the potential application of polyomavirus miRNA as a marker for the progression of polyomaviruses associated diseases and polyomaviruses reactivation is also included.

Indexed as

biomarkermiRNApersistent infectionpolyomavirusvirus replication

Identifiers

PMID33889147
PMCPMC8055838
OpenAlexW3142822746

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.