ArticleJournal of Indian Society of Periodontology
Analysis of collagen fibers in human gingival tissues using picrosirius red stain under polarized microscope.
Article in Journal of Indian Society of Periodontology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Blockage of P2X7 receptor activation attenuated bone loss in ligature-induced model of periodontitis in rats.Purinergic signalling · 2025Article
- Curcumin administration mitigates periodontitis-induced tissue damage in hypercholesterolemic rats: a natural preventive approach.Odontology · 2025Article
- Chamomile Tincture and Lidocaine Hydrochloride Gel Ameliorates Periodontitis: A Preclinical Study.Biomedicines · 2024Article
- Point-of-care diagnostic devices for periodontitis - current trends and urgent need.Sensors & diagnostics · 2024Review
- Brazilin cream fromPeerJ · 2024Article
- Mechanical Regulation of Oral Epithelial Barrier Function.Bioengineering (Basel, Switzerland) · 2023Article
- The Remodeling of Dermal Collagen Fibrous Structures in Mice under Zero Gravity: The Role of Mast Cells.International journal of molecular sciences · 2023Article
- Main Pathological Changes of Benign Ureteral Strictures.Frontiers in medicine · 2022Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCollagen fibers are the main element of gingival connective tissue and contribute a leading role in the preservation of structural integrity and tissue function. Hence, its degradation is regarded as the main marker of periodontal disease progression.
aimThe aim of this study is to analyze and compare collagen fibers, their birefringence pattern in healthy and in diseased gingival tissues stained using picrosirius red stain (PRS) and the polarizing microscope. MATERIALS AND
methodsA total of 90 participants screened were divided into the control group (healthy gingiva) and experimental group (moderate periodontitis and severe periodontitis) based on the clinical parameters. Gingival tissue sections were stained with PRS and observed under the polarized microscope to assess the type of collagen fibers in healthy and diseased gingival tissue. Statistical analysis was performed using the one-way ANOVA and Tukey multiple comparison test.
resultsThe healthy group revealed well-packed collagen in a parallel pattern with a strong birefringence, whereas in severe periodontitis group showed loosely packed collagen fibers in a haphazard pattern suggestive of severe destruction of the extracellular matrix. The moderate periodontitis group had a blended mixture of thick and thin fibers.
conclusionsCollagen fibers showed birefringence property when stained with PRS that helps in a better understanding of normal and pathological conditions.
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