ArticleNature immunology2021
Systems analysis and controlled malaria infection in Europeans and Africans elucidate naturally acquired immunity.
Abstract readClinical Trial, Phase I
In one paragraph
Article in Nature immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Immune responses associated with protection induced by chemoattenuated PfSPZ vaccine in malaria-naive Europeans.JCI insight · 2024Trial
- Malaria exposure history shapes PD-1 expression across human B-cell subsets during acute Plasmodium falciparum infection.BMC microbiology · 2026Article
- Comparison of CD4 T-Cell Response in Plasmodium falciparum and vivax Malaria.The Journal of infectious diseases · 2026Article
- Early-life immunological and microbial differences between East African and North European children.Communications medicine · 2026Article
- Imaging mass cytometry of the immune microenvironment in alveolar echinococcosis.Frontiers in cellular and infection microbiology · 2026Article
- Plasmodium falciparum infection induces T cell tolerance that is associated with decreased disease severity upon re-infection.The Journal of experimental medicine · 2025Article
- Systems analysis unravels a common rural-urban gradient in immunological profile, function, and metabolic dependencies.Science advances · 2025Article
- Malaria exposure remodels the plasma proteome of Ghanaian children.BMC infectious diseases · 2025Article
- Multi-dimensional analysis of B cells reveals the expansion of memory and regulatory B-cell clusters in humans living in rural tropical areas.Clinical and experimental immunology · 2025Article
- Spatially resolved single-cell atlas unveils a distinct cellular signature of fatal lung COVID-19 in a Malawian population.Nature medicine · 2024Article
- Lifestyle score is associated with cellular immune profiles in healthy Tanzanian adults.Brain, behavior, & immunity - health · 2024Article
- PfSPZ Vaccine induces focused humoral immune response in HIV positive and negative Tanzanian adults.EBioMedicine · 2024Article
- The impact of Plasmodium-driven immunoregulatory networks on immunity to malaria.Nature reviews. Immunology · 2024Review
- Controlled human hookworm infection remodels plasmacytoid dendritic cells and regulatory T cells towards profiles seen in natural infections in endemic areas.Nature communications · 2024Article
- Machine learning prediction of malaria vaccine efficacy based on antibody profiles.PLoS computational biology · 2024Article
- Immunological factors linked to geographical variation in vaccine responses.Nature reviews. Immunology · 2024Review
- scRNA-seq reveals elevated interferon responses and TNF-α signaling via NFkB in monocytes in children with uncomplicated malaria.Experimental biology and medicine (Maywood, N.J.) · 2024Article
- Plasmodium knowlesi in pig-tailed macaques: a potential new model for malaria vaccine research.Malaria journal · 2023Article
- CD4 T Cell-Dependent and -Independent Roles for IFN-γ in Blood-Stage Malaria.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Distinct immune responses associated with vaccination status and protection outcomes after malaria challenge.PLoS pathogens · 2023Article
Corrections and comments
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Authors and funding
27 authors.
Sanne E de JongDepartment of Parasitology, Leiden University Center for Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-6696-7359
Vincent van Unen *Department of Parasitology, Leiden University Center for Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0001-9339-8430
Mikhael D Manurung *Department of Parasitology, Leiden University Center for Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0003-2728-1829
Koen A Stam *Department of Parasitology, Leiden University Center for Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0003-0982-4439
Jelle J GoemanDepartment of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0003-4283-0259
Simon P JochemsDepartment of Parasitology, Leiden University Center for Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-4835-1032
Thomas HölltDepartment of Intelligent Systems, Delft University of Technology, Delft, the Netherlands.ORCID http://orcid.org/0000-0001-8125-1650
Nicola PezzottiDepartment of Intelligent Systems, Delft University of Technology, Delft, the Netherlands.
Yoanne D MouwendaDepartment of Parasitology, Leiden University Center for Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-5827-419X
Madeleine Eunice Betouke OngweDepartment of Parasitology, Leiden University Center for Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-4206-1333
Freia-Raphaella LorenzInstitute of Tropical Medicine, University of Tübingen, Tübingen, Germany.ORCID http://orcid.org/0000-0002-7401-2720
Yvonne C M KruizeDepartment of Parasitology, Leiden University Center for Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, the Netherlands.
Shohreh AzimiDepartment of Parasitology, Leiden University Center for Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-3117-5722
Marion H KönigDepartment of Parasitology, Leiden University Center for Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, the Netherlands.
Anna VilanovaDepartment of Intelligent Systems, Delft University of Technology, Delft, the Netherlands.ORCID http://orcid.org/0000-0002-1034-737X
Elmar EisemannDepartment of Intelligent Systems, Delft University of Technology, Delft, the Netherlands.ORCID http://orcid.org/0000-0003-4153-065X
Boudewijn P F LelieveldtDepartment of Intelligent Systems, Delft University of Technology, Delft, the Netherlands.ORCID http://orcid.org/0000-0001-8269-7603
Meta RoestenbergDepartment of Parasitology, Leiden University Center for Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-5052-2830
B Kim Lee SimSanaria Inc., Rockville, MD, USA.
Marcel J T ReindersDepartment of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-1148-1562
Rolf FendelInstitute of Tropical Medicine, University of Tübingen, Tübingen, Germany.ORCID http://orcid.org/0000-0003-4716-0311
Stephen L HoffmanSanaria Inc., Rockville, MD, USA.
Peter G KremsnerCenter of Medical Research Lambaréné (CERMEL), Lambaréné, Gabon.ORCID http://orcid.org/0000-0002-3926-4113
Frits KoningDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-4007-5715
Benjamin MordmüllerCenter of Medical Research Lambaréné (CERMEL), Lambaréné, Gabon.ORCID http://orcid.org/0000-0001-9101-2768
Bertrand LellCenter of Medical Research Lambaréné (CERMEL), Lambaréné, Gabon.
Maria YazdanbakhshDepartment of Parasitology, Leiden University Center for Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, the Netherlands. M.Yazdanbakhsh@lumc.nl.ORCID http://orcid.org/0000-0002-7666-1441
Funding
No grant is acknowledged in the PubMed record.
Abstract
Controlled human infections provide opportunities to study the interaction between the immune system and malaria parasites, which is essential for vaccine development. Here, we compared immune signatures of malaria-naive Europeans and of Africans with lifelong malaria exposure using mass cytometry, RNA sequencing and data integration, before and 5 and 11 days after venous inoculation with Plasmodium falciparum sporozoites. We observed differences in immune cell populations, antigen-specific responses and gene expression profiles between Europeans and Africans and among Africans with differing degrees of immunity. Before inoculation, an activated/differentiated state of both innate and adaptive cells, including elevated CD161
Indexed as
Adaptive ImmunityAdolescentAdultAntibodies, ProtozoanAntigens, ProtozoanBlack PeopleDendritic CellsDisease SusceptibilityFemaleHealthy VolunteersHost-Parasite InteractionsHumansImmunity, InnateInterferon-gammaMalaria, FalciparumMaleAntibodies, ProtozoanAntigens, ProtozoanIFNG protein, humanInterferon-gamma
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PMID
33888898What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.