Evidence map›Paper›PMID 33888856›Full record

ArticleNPJ digital medicine2021

AI-based analysis of CT images for rapid triage of COVID-19 patients.

Qinmei Xu, Xianghao Zhan, Zhen Zhou, Yiheng Li, Peiyi Xie, Shu Zhang, Xiuli Li, Yizhou Yu, Changsheng Zhou, Longjiang Zhang and 2 more

Abstract read
In one paragraph

Article in NPJ digital medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

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  17. Data science in the intensive care unit.World journal of critical care medicine · 2022
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Qinmei Xu *Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, China.ORCID http://orcid.org/0000-0001-7200-0817
Xianghao Zhan *Department of Bioengineering, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-7058-2603
Zhen ZhouDeepwise AI Lab, Deepwise Inc., Beijing, China.
Yiheng LiDepartment of Biomedical Data Science, Stanford University, Stanford, CA, USA.
Peiyi XieStanford Center for Biomedical Informatics Research (BMIR), Department of Medicine, Stanford University, Stanford, CA, USA.
Shu ZhangDeepwise AI Lab, Deepwise Inc., Beijing, China.
Xiuli LiDeepwise AI Lab, Deepwise Inc., Beijing, China.
Yizhou YuDeepwise AI Lab, Deepwise Inc., Beijing, China.
Changsheng ZhouDepartment of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, China.
Longjiang ZhangDepartment of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, China.
Olivier GevaertStanford Center for Biomedical Informatics Research (BMIR), Department of Medicine, Stanford University, Stanford, CA, USA. ogevaert@stanford.edu.ORCID http://orcid.org/0000-0002-9965-5466
Guangming LuDepartment of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, China. cjr.luguangming@vip.163.com.ORCID http://orcid.org/0000-0003-4913-2314

Funding

Radiogenomics Framework for Non-Invasive Personalized MedicineR01EB020527 · NIBIB · STANFORD UNIVERSITY · PI GEVAERT, OLIVIER · 2015 to 2018
$2.3M
Radiogenomics framework for non-invasive personalized medicineR56EB020527 · NIBIB · STANFORD UNIVERSITY · PI GEVAERT, OLIVIER · 2019 to 2019
$444k
NIBIB NIH HHS R01 EB020527NIBIB NIH HHS R56 EB020527
6 · The paper itself

Abstract

The COVID-19 pandemic overwhelms the medical resources in the stressed intensive care unit (ICU) capacity and the shortage of mechanical ventilation (MV). We performed CT-based analysis combined with electronic health records and clinical laboratory results on Cohort 1 (n = 1662 from 17 hospitals) with prognostic estimation for the rapid stratification of PCR confirmed COVID-19 patients. These models, validated on Cohort 2 (n = 700) and Cohort 3 (n = 662) constructed from nine external hospitals, achieved satisfying performance for predicting ICU, MV, and death of COVID-19 patients (AUROC 0.916, 0.919, and 0.853), even on events happened two days later after admission (AUROC 0.919, 0.943, and 0.856). Both clinical and image features showed complementary roles in prediction and provided accurate estimates to the time of progression (p < 0.001). Our findings are valuable for optimizing the use of medical resources in the COVID-19 pandemic. The models are available here: https://github.com/terryli710/COVID_19_Rapid_Triage_Risk_Predictor .

Identifiers

PMID33888856
PMCPMC8062628

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.