ArticleCommunications biology2021
Lepidopteran wing scales contain abundant cross-linked film-forming histidine-rich cuticular proteins.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 30 citations in OpenAlex.
- Functional analysis of down-regulated CYP6AE gene clusters involved in the insecticidal mechanism of lycorine against Spodoptera litura.Pest management science · 2026Article
- Camptothecin weakens the mechanical properties of insect cuticle by inhibiting tanning.Insect science · 2026Article
- Hierarchical woven fibrillar structures in developing single gyroids in butterflies.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Gustatory receptors interact with the serotonin pathway to regulate silkmoth stereotyped courtship behavior.BMC biology · 2025Article
- Nanoscale cuticle mass density variations influenced by pigmentation in butterfly wing scales.Nature communications · 2025Article
- Catecholamines Differ in Their Capacity to Form Melanin.microPublication biology · 2025Article
- A long noncoding RNA at theProceedings of the National Academy of Sciences of the United States of America · 2024Article
- The BTB-ZF geneeLife · 2024Article
- TALEN-mediated homologous-recombination-based fibroin light chain in-fusion expression system inFrontiers in bioengineering and biotechnology · 2024Article
- Chromosomal-level Genome Assembly of the Coffee Bee Hawk Moth Reveals the Evolution of Chromosomes and the Molecular Basis of Distinct Phenotypes.Genome biology and evolution · 2023Article
- Genome-Wide Identification and Transcriptome-Based Expression Profile of Cuticular Protein Genes inInternational journal of molecular sciences · 2023Article
- Metabolite Changes in Orange Dead Leaf ButterflyMetabolites · 2022Article
- A Blueprint of Microstructures and Stage-Specific Transcriptome Dynamics of Cuticle Formation inInternational journal of molecular sciences · 2022Article
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Authors and funding
20 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Scales are symbolic characteristic of Lepidoptera; however, nothing is known about the contribution of cuticular proteins (CPs) to the complex patterning of lepidopteran scales. This is because scales are resistant to solubilization, thus hindering molecular studies. Here we succeeded in dissolving developing wing scales from Bombyx mori, allowing analysis of their protein composition. We identified a distinctive class of histidine rich (His-rich) CPs (6%-45%) from developing lepidopteran scales by LC-MS/MS. Functional studies using RNAi revealed CPs with different histidine content play distinct and critical roles in constructing the microstructure of the scale surface. Moreover, we successfully synthesized films in vitro by crosslinking a 45% His-rich CP (BmorCPR152) with laccase2 using N-acetyl- dopamine or N-β-alanyl-dopamine as the substrate. This molecular study of scales provides fundamental information about how such a fine microstructure is constructed and insights into the potential application of CPs as new biomaterials.
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