ArticleScientific reports2021
Several frailty parameters highly prevalent in middle age (50-65) are independent predictors of adverse events.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Inappropriate prescribing and association with readmission or mortality in hospitalised older adults with frailty: a systematic review and meta-analysis.BMC geriatrics · 2024Pooled it
- Associations of Midlife Gait Speed and Muscle Performance With Falls in Later Life: Secondary Analysis of the MIDUS Cohort.JMIR aging · 2026Article
- Serum Periostin as a Complementary Biomarker of Frailty in Type 2 Diabetes: A Pilot Study Using the FRAIL Scale.International journal of molecular sciences · 2026Article
- Factors associated with sustained robustness in older adults: an 8-year multinational longitudinal study using SHARE data.BMC geriatrics · 2026Observational
- Identification of Frailty Subtypes in African American Adults With and Without Type 2 Diabetes: A Latent Class Analysis From the Jackson Heart Study.Diabetes, obesity & metabolism · 2026Article
- Reliability and Validity of Oral Frailty Index-8: Findings Among Community-Dwelling Adults in Singapore.Journal of oral rehabilitation · 2026Article
- Association between frailty and fall risk in elderly patients with knee osteoarthritis in community: a propensity score matching analysis.Scientific reports · 2026Article
- Impact of physical activity and frailty on mortality and utilization among middle-aged and older adults in South Korea.The Journal of frailty & aging · 2026Article
- Article
- Community Health Perspectives on Middle-aged Adults Living Alone: A Scoping Review.Journal of community health · 2026Article
- Frailty Modifies the Prognostic Effect of Age Among Older Adults With Acute Coronary Syndrome.Journal of the American Heart Association · 2026Observational
- Article
- Assessing the Tools for Assessing Frailty.JACC. Asia · 2025Article
- Frailty is associated with poor outcomes in midlife trauma patients.American journal of surgery · 2025Article
- Article
- Differential effects of size-specific particulate matter on frailty transitions among middle-aged and older adults in China: findings from the China Health and Retirement Longitudinal Study (CHARLS), 2015-2018.International health · 2024Article
- Sex differences in the frailty phenotype and mortality in the I-Lan longitudinal aging study cohort.BMC geriatrics · 2024Article
- Frailty among middle-aged and older women and men in India: findings from wave 1 of the longitudinal Ageing study in India.BMJ open · 2023Article
- Frailty in mid-life predicts outcome following trauma.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2023Article
- Baduanjin exercise for balance function in community-dwelling older adults with cognitive frailty: a randomized controlled trial protocol.BMC complementary medicine and therapies · 2022Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although frailty can arise in middle age, very few studies have investigated frailty before 65 years. Our objectives were to assess the prevalence of frailty parameters in middle-aged individuals and probe the association with future adverse events. We performed cross-sectional and longitudinal analyses of community-dwelling individuals aged 50 to 65 (n = 411, median age: 59.0) having undergone a multidomain geriatric assessment (2010-2015) in an outpatient clinic in the greater Paris area of France (SUCCEED cohort). The primary outcome was a composite measure of adverse events (non-accidental falls, fractures, unplanned hospitalizations, death), recorded in 2016/2017. Multivariable logistic regression models were built to identify independent predictors. Six frailty parameters were highly prevalent (> 20%): low activity (40.1%), exhaustion (31.3%), living alone (28.5%), balance impairment (26.8%), weakness (26.7%), and executive dysfunction (23.2%). Female sex (odds ratio: 2.67 [95% confidence interval: 1.17-6.11]), living alone (2.39 [1.32-4.33]), balance impairment (2.09 [1.16-3.78]), executive dysfunction (2.61, [1.18-5.77]), and exhaustion (2.98 [1.65-5.39]) were independent predictors of adverse events. Many frailty parameters are already altered in middle-aged individuals and are predictive of adverse health events. Our findings highlight a possible need for frailty screening and preventive programs targeting middle-aged individuals.
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