ArticleScientific reports2021
Feasibility of CT-derived myocardial strain measurement in patients with advanced cardiac valve disease.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- Multidimensional cardiac functional phenotyping beyond ejection fraction: a multimodality imaging framework for cardiovascular care.Frontiers in cardiovascular medicine · 2026Review
- Clinical application of cardiac computed tomography in cardiomyopathy.The international journal of cardiovascular imaging · 2026Review
- Multi-chamber three-dimensional myocardial strain assessment by computed tomography: a comparison with speckle tracking echocardiography and association with pulmonary hypertension in severe aortic stenosis.Frontiers in cardiovascular medicine · 2026Article
- Impact of Aortic Stenosis Severity on Left Heart Function Analyzed Using CT-Derived Strain Parameters.Korean journal of radiology · 2025Article
- Myocardial extracellular volume fraction with spectral detector computed tomography for risk stratification in non-ischemic heart failure.La Radiologia medica · 2025Article
- Cardiovascular imaging techniques for electrophysiologists.Nature cardiovascular research · 2025Review
- Functional myocardial assessment in cine cardiac computerized tomographic angiography using echocardiographic feature-tracking software in patients with and without significant coronary disease.International journal of cardiology. Heart & vasculature · 2025Article
- Article
- Evolving perspectives on aortic stenosis: the increasing importance of evaluating the right ventricle before aortic valve intervention.Frontiers in cardiovascular medicine · 2024Review
- Milestones in CT: Past, Present, and Future.Radiology · 2023Review
- Improvement in cardiac function and regional LV strain following intramyocardial injection of a theranostic hydrogel early postmyocardial infarction in a porcine model.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Computational Analysis of Cardiac Contractile Function.Current cardiology reports · 2022Review
- Environmental Tobacco Smoke Exposure Estimated Using the SHSES Scale, and Feature Tracking Computed Tomography-Derived Left Ventricular Global Longitudinal Strain in Hypertensive Patients.Cardiovascular toxicology · 2022Article
- Visualizing diastolic failure: Non-invasive imaging-biomarkers in patients with heart failure with preserved ejection fraction.EBioMedicine · 2022Review
- Regional left ventricular endocardial strains estimated from low-dose 4DCT: Comparison with cardiac magnetic resonance feature tracking.Medical physics · 2022Article
- Reproducibility of global and segmental myocardial strain using cine DENSE at 3 T: a multicenter cardiovascular magnetic resonance study in healthy subjects and patients with heart disease.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2022Article
- Novel Cardiac Computed Tomography Methods for the Assessment of Anthracycline Induced Cardiotoxicity.Frontiers in cardiovascular medicine · 2022Review
- Left ventricular longitudinal strain is a major determinant of CT-derived three-dimensional maximum principal strain: comparison with two-dimensional speckle tracking echocardiography.Heart and vessels · 2022Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To explore the feasibility of CT-derived myocardial strain measurement in patients with advanced cardiac valve disease and to compare it to strain measurements derived from transthoracic echocardiography (TTE). 43 consecutive patients with advanced cardiac valve disease and clinically indicated retrospectively gated cardiac CTs were retrospectively analyzed. The longitudinal, circumferential as well as radial systolic strain were determined in all patients utilizing a commercially available CT strain software. In 36/43 (84%) patients, CT-derived longitudinal strain was compared to speckle-tracking TTE. Pearson's correlation coefficients as well as Bland-Altman analysis were used to compare the CT-derived strain measurements to TTE. The intra- and inter-reader-reliability of the CT-derived strain measurements were assessed by intra-class correlation coefficients (ICCs). Strain measurements were feasible in all patients. CT-derived global longitudinal strain (GLS) correlated moderately with TTE-derived GLS (r = 0.6, p < 0.001). A moderate correlation between CT-derived GLS and CT-derived left ventricular ejection fraction was found (LVEF, r = - 0.66, p = 0.036). Bland-Altman analysis showed a systematic underestimation of myocardial strain by cardiac CT compared to TTE (mean difference: - 5.8%, 95% limit of agreement between - 13.3 and 1.8%). Strain measurements showed an excellent intra- and inter-reader-reliability with an intra-reader ICC of 1.0 and an inter-reader ICC of 0.99 for GLS measurements. CT-derived myocardial strain measurements are feasible in patients with advanced cardiac valve disease. They are highly reproducible and correlate with established parameters of strain measurements. Our results encourage the implementation of CT-derived strain measurement into clinical routine.
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