Evidence map›Paper›PMID 33888826›Full record

ArticleScientific reports2021

C subunit of the ATP synthase is an amyloidogenic calcium dependent channel-forming peptide with possible implications in mitochondrial permeability transition.

Giuseppe Federico Amodeo, Brenda Yasie Lee, Natalya Krilyuk, Carina Teresa Filice, Denis Valyuk, Daniel Erik Otzen, Sergey Noskov, Zoya Leonenko, Evgeny V Pavlov

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 28 citations in OpenAlex.

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  14. Reversible binding of divalent cations toFrontiers in molecular biosciences · 2023
    Review
  15. Review
  16. Article
  17. Review
  18. ATP synthase FCellular and molecular life sciences : CMLS · 2022
    Review
  19. Inorganic Polyphosphate in Mitochondrial Energy Metabolism and Pathology.Progress in molecular and subcellular biology · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Giuseppe Federico AmodeoDepartment of Molecular Pathobiology, New York University College of Dentistry, 345 East 24th Street, New York, NY, 10010-4086, USA.
Brenda Yasie LeeDepartment of Physics and Astronomy, University of Waterloo, Waterloo, Canada.
Natalya KrilyukDepartment of Molecular Pathobiology, New York University College of Dentistry, 345 East 24th Street, New York, NY, 10010-4086, USA.
Carina Teresa FiliceDepartment of Physics and Astronomy, University of Waterloo, Waterloo, Canada.
Denis ValyukDepartment of Molecular Pathobiology, New York University College of Dentistry, 345 East 24th Street, New York, NY, 10010-4086, USA.
Daniel Erik OtzenInterdisciplinary Nanoscience Center (iNANO) and Department of Molecular Biology and Genetics, Aarhus University, Aarhus C, Denmark.
Sergey NoskovCentre for Molecular Simulation and Biochemistry Research Cluster, Department of Biological Sciences, University of Calgary, Calgary, Canada.
Zoya LeonenkoDepartment of Physics and Astronomy, University of Waterloo, Waterloo, Canada.
Evgeny V PavlovDepartment of Molecular Pathobiology, New York University College of Dentistry, 345 East 24th Street, New York, NY, 10010-4086, USA. ep37@nyu.edu.
New York University · USUniversity of Waterloo · CAAarhus University · DKUniversity of Calgary · CA

Funding

Molecular composition of the mitochondrial permeability transition poreR01GM115570 · NIGMS · NEW YORK UNIVERSITY · PI PAVLOV, EVGENY · 2016 to 2020
$1.8M
NIGMS NIH HHS R01 GM115570
6 · The paper itself

Abstract

The c subunit is an inner mitochondrial membrane (IMM) protein encoded by three nuclear genes. Best known as an integral part of the F

Indexed as

Amino Acid SequenceAmyloid beta-PeptidesCalcium ChannelsCircular DichroismHumansMicroscopy, Atomic ForceMitochondrial Permeability Transition PoreMitochondrial Proton-Translocating ATPasesProtein ConformationAmyloid beta-PeptidesCalcium ChannelsMitochondrial Permeability Transition PoreMitochondrial Proton-Translocating ATPases

Identifiers

PMID33888826
PMCPMC8062469
OpenAlexW3153066160

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.