ArticleScientific reports2021
Anti-inflammatory activity of psoralen in human periodontal ligament cells via estrogen receptor signaling pathway.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Psoralen enhances direct cardiac reprogramming via activating PPARα and driving mitochondrial fission and improves cardiac function after myocardial infarction.Stem cell research & therapy · 2026Article
- Endocrine Regulation of Osteoporosis: Insights from the Brain-Bone Axis Theory.Journal of bone metabolism · 2025Article
- Integrative metabolomics and system pharmacology reveal the antioxidant blueprint of Psoralea corylifolia.Scientific reports · 2025Article
- Estrogen prevented gingival barrier injury fromInfection and immunity · 2025Article
- Isoschaftoside in Fig Leaf Tea Alleviates Nonalcoholic Fatty Liver Disease in Mice via the Regulation of Macrophage Polarity.Nutrients · 2025Article
- The impact of estrogen on periodontal tissue integrity and inflammation-a mini review.Frontiers in dental medicine · 2025Review
- PSO/SDF-1 composite hydrogel promotes osteogenic differentiation of PDLSCs and bone regeneration in periodontitis rats.Heliyon · 2024Article
- Natural Products with Potential Effects on Hemorrhoids: A Review.Molecules (Basel, Switzerland) · 2024Review
- Identification of potential diagnostic biomarkers associated with periodontitis by comprehensive bioinformatics analysis.Scientific reports · 2024Article
- Psoralen Isolated from the Roots ofMediators of inflammation · 2024Article
- Decoding nature: multi-target anti-inflammatory mechanisms of natural products in the TLR4/NF-κB pathway.Frontiers in pharmacology · 2024Review
- Effect of psoralen on the regulation of osteogenic differentiation induced by periodontal stem cell-derived exosomes.Human cell · 2023Article
- Antioxidant and Anti-Inflammatory Properties of Phytochemicals Found in theAntioxidants (Basel, Switzerland) · 2023Review
- Isodorsmanin A Prevents Inflammatory Response in LPS-Stimulated Macrophages by Inhibiting the JNK and NF-κB Signaling Pathways.Current issues in molecular biology · 2023Article
- Quercetin inhibits the activity and function of dendritic cells through the TLR4/IRAK4/NF-κB signalling pathway.Contemporary oncology (Poznan, Poland) · 2023Article
- Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Psoralen is one of the most effective ingredients extracted from the Chinese herb, Psoralea corylifolia L. Studies have found that psoralen has anti-inflammatory and estrogen-like effects; however, little research has been conducted to elucidate the mechanisms underlying these effects. Through the molecule docking assay, psoralen was found to have a better combination with ERα than ERβ. In human periodontal ligament cells, psoralen was found to upregulate the estrogen target genes (e.g., CTSD, PGR, TFF1) and down-regulate the expression of inflammatory cytokines (TNF-α, IL-1β, IL-6 and IL-8) stimulated by P. gingivalis LPS, as well as TLR4-IRAK4-NF-κb signaling pathway proteins. These effects were reversed by the ER antagonist ICI 182780. These results indicated that psoralen may exert anti-inflammatory effects as an agonist to ER, which could provide a theoretical basis for the use of psoralen for adjuvant therapy and prevention of periodontitis.
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Registered trials
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