ArticleScientific reports2021
Eye-tracking indices of impaired encoding of visual short-term memory in familial Alzheimer's disease.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Eyes on dementia: an overview of the interplay between eye movements and cognitive decline.Journal of medicine and life · 2023Pooled it
- Eye tracking as a digital biomarker in neurodegenerative diseases.Journal of neurology · 2026Review
- Collection of the digital data from the neurological examination.NPJ digital medicine · 2025Article
- Multimodal Digital Phenotyping of Behavior in a Neurology Clinic: Development of the Neurobooth Platform and the First Two Years of Data Collection.medRxiv : the preprint server for health sciences · 2025Article
- Development of an eye-tracking system based on a deep learning model to assess executive function in patients with mental illnesses.Scientific reports · 2024Article
- Cortical activation in elderly patients with Alzheimer's disease dementia during working memory tasks: a multichannel fNIRS study.Frontiers in aging neuroscience · 2024Article
- A novel eye-movement impairment in multiple sclerosis indicating widespread cortical damage.Brain : a journal of neurology · 2023Article
- Eye-tracking paradigms for the assessment of mild cognitive impairment: a systematic review.Frontiers in psychology · 2023Review
- Article
- A novel deep learning approach for diagnosing Alzheimer's disease based on eye-tracking data.Frontiers in human neuroscience · 2022Article
- Salient Cognitive Paradigms to Assess Preclinical Alzheimer's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022Review
- Analysis of Features of Alzheimer's Disease: Detection of Early Stage from Functional Brain Changes in Magnetic Resonance Images Using a Finetuned ResNet18 Network.Diagnostics (Basel, Switzerland) · 2021Article
- Eye tracking as a diagnostic tool in Alzheimer's disease, mild cognitive impairment, and related dementias: a systematic review.Alzheimer's & dementia (Amsterdam, Netherlands)Review
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
Abstract
The basis of visual short-term memory (VSTM) impairments in preclinical Alzheimer's disease (AD) remains unclear. Research suggests that eye movements may serve as indirect surrogates to investigate VSTM. Yet, investigations in preclinical populations are lacking. Fifty-two individuals from a familial Alzheimer's disease (FAD) cohort (9 symptomatic carriers, 17 presymptomatic carriers and 26 controls) completed the "Object-localisation" VSTM task while an eye-tracker recorded eye movements during the stimulus presentation. VSTM function and oculomotor performance were compared between groups and their association during encoding investigated. Compared to controls, symptomatic FAD carriers showed eye movement patterns suggestive of an ineffective encoding and presymptomatic FAD carriers within 6 years of their expected age at symptom onset, were more reliant on the stimuli fixation time to achieve accuracy in the localisation of the target. Consequently, for shorter fixation times on the stimuli, presymptomatic carriers were less accurate at localising the target than controls. By contrast, the only deficits detected on behavioural VSTM function was in symptomatic individuals. Our findings provide novel evidence that encoding processes may be vulnerable and weakened in presymptomatic FAD carriers, most prominently for spatial memory, suggesting a possible explanation for the subtle VSTM impairments observed in the preclinical stages of AD.
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