Evidence map›Paper›PMID 33888718›Full record

ArticleNature communications2021

Neurexins regulate presynaptic GABA

Fujun Luo, Alessandra Sclip, Sean Merrill, Thomas C Südhof

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. Article
  3. Ethanol Alters the Neurexin Landscape in Human Neuroblastoma Cells.Alcohol, clinical & experimental research · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Alpha-neurexins in health and disease.Frontiers in molecular neuroscience · 2025
    Review
  10. Article
  11. Monoallelic de novoScience advances · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Fujun Luo *Department of Molecular and Cellular Physiology and Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA, USA. luo_fujun@grmh-gdl.cn.ORCID 0000-0001-9487-6545
Alessandra Sclip *Department of Molecular and Cellular Physiology and Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA, USA.ORCID 0000-0002-9313-4176
Sean MerrillDepartment of Molecular and Cellular Physiology and Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA, USA.
Thomas C SüdhofDepartment of Molecular and Cellular Physiology and Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA, USA.ORCID 0000-0003-3361-9275
Howard Hughes Medical Institute · US

Funding

Function of NeurexinsR01MH052804 · NIMH · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI SUDHOF, THOMAS C. · 1994 to 2024
$3.7M
NIMH NIH HHS R01 MH052804
6 · The paper itself

Abstract

Diverse signaling complexes are precisely assembled at the presynaptic active zone for dynamic modulation of synaptic transmission and synaptic plasticity. Presynaptic GABA

Indexed as

AnimalsBrain StemCA1 Region, HippocampalCA3 Region, HippocampalCalcium-Binding ProteinsCerebellumgamma-Aminobutyric AcidMiceMice, KnockoutModels, AnimalNerve Tissue ProteinsNeural Cell Adhesion MoleculesNeuronal PlasticityPatch-Clamp TechniquesPyramidal CellsReceptors, GABA-BCalcium-Binding Proteinsgamma-Aminobutyric AcidNerve Tissue ProteinsNeural Cell Adhesion Moleculesneurexin 3, mouseneurexin IINrxn1 protein, mouseReceptors, GABA-B

Identifiers

PMID33888718
PMCPMC8062527
OpenAlexW3156903971

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.