ArticleNature communications2021
Structural variation at the maize WUSCHEL1 locus alters stem cell organization in inflorescences.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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46 citing papers in PubMed, 73 citations in OpenAlex.
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- Identification of a pleiotropic QTL and candidate genes underlying ear traits of maize (Zea mays L.) through controlling the activity of inflorescence meristem.BMC genomics · 2026Article
- Phenomics-derived temporal maize health and environmental index enhance physiology-informed genomic prediction of yield across environments.Plant physiology · 2026Article
- Serial Spatial Transcriptomes Reveal Regulatory Transitions in Maize Leaf Development.Plant biotechnology journal · 2026Article
- Wheat TaSPL13-2B Improves Floret Fertility and Enhances Grain Number per Spikelet Through Jasmonic Acid Signalling Pathway.Plant biotechnology journal · 2026Article
- ERECTA genes and their ligands regulate shoot and inflorescence architecture in maize.Nature communications · 2026Article
- Novel genome editing approaches to manipulate apical meristem activity for crop yield.Frontiers in plant science · 2026Review
- Pangenome-driven discovery and comparative genomics of glycosyltransferase genes inFrontiers in plant science · 2026Article
- Large-scale single-cell profiling of stem cells identifies redundant regulators of shoot development and yield trait variation.Developmental cell · 2025Article
- Upstairs, downstairs: conserved and divergent CLAVATA signalling in shoot meristem development and root symbioses.Annals of botany · 2025Review
- Decades' progress and prospects on maize functional genomics and molecular breeding.Science China. Life sciences · 2025Review
- Article
- WUSCHEL-dependent chromatin regulation in maize inflorescence development at single-cell resolution.Genome biology · 2025Article
- Genome-Wide Association Analysis of Fresh Maize.International journal of molecular sciences · 2025Article
- How meristems shape plant architecture in cereals-Cereal Stem Cell Systems (CSCS) Consortium.The Plant cell · 2025Review
- RPAD locus controls prostrate growth habit in Oryza nivara.The plant genome · 2025Article
- Functional analysis of the woody oil crop Plukenetia volubilis L. LEC2 homolog PvoB3-69 in promoting regeneration.Plant cell reports · 2025Article
- Chromosomal inversion at the DG1 promoter drives double-grain spikelets and enhances grain yield in sorghum.Nature plants · 2025Article
- CRISPR/Cas9: a sustainable technology to enhance climate resilience in major Staple Crops.Frontiers in genome editing · 2025Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Structural variation in plant genomes is a significant driver of phenotypic variability in traits important for the domestication and productivity of crop species. Among these are traits that depend on functional meristems, populations of stem cells maintained by the CLAVATA-WUSCHEL (CLV-WUS) negative feedback-loop that controls the expression of the WUS homeobox transcription factor. WUS function and impact on maize development and yield remain largely unexplored. Here we show that the maize dominant Barren inflorescence3 (Bif3) mutant harbors a tandem duplicated copy of the ZmWUS1 gene, ZmWUS1-B, whose novel promoter enhances transcription in a ring-like pattern. Overexpression of ZmWUS1-B is due to multimerized binding sites for type-B RESPONSE REGULATORs (RRs), key transcription factors in cytokinin signaling. Hypersensitivity to cytokinin causes stem cell overproliferation and major rearrangements of Bif3 inflorescence meristems, leading to the formation of ball-shaped ears and severely affecting productivity. These findings establish ZmWUS1 as an essential meristem size regulator in maize and highlight the striking effect of cis-regulatory variation on a key developmental program.
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