Evidence map›Paper›PMID 33888714›Full record

ArticleNature communications2021

J-aggregates of meso-[2.2]paracyclophanyl-BODIPY dye for NIR-II imaging.

Kang Li, Xingchen Duan, Zhiyong Jiang, Dan Ding, Yuncong Chen, Guo-Qiang Zhang, Zhipeng Liu

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
16.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 275 citations in OpenAlex.

  1. Review
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  5. Review
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  7. Article
  8. Review
  9. Self-Assembled (Aza)BODIPY Dyes for Biomedical in Vivo Imaging.Angewandte Chemie (International ed. in English) · 2026
    Review
  10. Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Kang Li *College of Materials Science and Engineering, Nanjing Forestry University, Nanjing, China.
Xingchen Duan *Key Laboratory of Bioactive Materials, Ministry of Education, and College of Life Sciences, Nankai University, Tianjin, China.
Zhiyong JiangCollege of Materials Science and Engineering, Nanjing Forestry University, Nanjing, China.
Dan DingKey Laboratory of Bioactive Materials, Ministry of Education, and College of Life Sciences, Nankai University, Tianjin, China.ORCID 0000-0003-1873-6510
Yuncong ChenState Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China. chenyc@nju.edu.cn.ORCID 0000-0002-8406-4866
Guo-Qiang ZhangKey Laboratory of Bioactive Materials, Ministry of Education, and College of Life Sciences, Nankai University, Tianjin, China. guoqiangzhang@mail.nankai.edu.cn.ORCID 0000-0003-4634-8996
Zhipeng LiuCollege of Materials Science and Engineering, Nanjing Forestry University, Nanjing, China. zpliu@njfu.edu.cn.ORCID 0000-0002-5458-9362
Nanjing Forestry University · CNNankai University · CNNanjing University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

J-aggregation is an efficient strategy for the development of fluorescent imaging agents in the second near-infrared window. However, the design of the second near-infrared fluorescent J-aggregates is challenging due to the lack of suitable J-aggregation dyes. Herein, we report meso-[2.2]paracyclophanyl-3,5-bis-N,N-dimethylaminostyrl BODIPY (PCP-BDP2) as an example of BODIPY dye with J-aggregation induced the second near-infrared fluorescence. PCP-BDP2 shows an emission maximum at 1010 nm in the J-aggregation state. Mechanism studies reveal that the steric and conjugation effect of the PCP group on the BODIPY play key roles in the J-aggregation behavior and photophysical properties tuning. Notably, PCP-BDP2 J-aggregates can be utilized for lymph node imaging and fluorescence-guided surgery in the nude mouse, which demonstrates their potential clinical application. This study demonstrates BODIPY dye as an alternate J-aggregation platform for developing the second near-infrared imaging agents.

Indexed as

AnimalsBoron CompoundsCell Line, TumorDisease Models, AnimalFluorescenceFluorescent DyesHumansInfrared RaysIntravital MicroscopyLymphatic SystemMiceOptical ImagingPeritoneal NeoplasmsVideo-Assisted Surgery4,4-difluoro-4-bora-3a,4a-diaza-s-indaceneBoron CompoundsFluorescent Dyes

Identifiers

PMID33888714
PMCPMC8062432
OpenAlexW3153227329

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.