ArticleNature communications2021
An alternative approach to nucleic acid memory.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed.
- Enhanced electrochemically-directed oligonucleotide synthesis via porous silica thin-film for DNA data storage.Microsystems & nanoengineering · 2026Article
- DNA Data Storage Architecture via Ligation of Dynamic DNA Bytes.Small methods · 2026Article
- Optimising DNA origami assembly by reducing off-target interactions.Nature communications · 2026Article
- DNA Helix Bundle-Encoded Multi-Bit Information Readout by Sapphire-Supported Nanopores.Advanced functional materials · 2026Article
- Two-dimensional data storage using a DNA molecular register.Frontiers in bioengineering and biotechnology · 2026Article
- Linked data storage using DNA origami nanostructures.Nature communications · 2025Article
- High-speed 3D DNA PAINT and unsupervised clustering for unlocking 3D DNA origami cryptography.Nature communications · 2025Article
- Breaking of the Up-Down Symmetry of DNA Origami on a Solid Substrate.Angewandte Chemie (International ed. in English) · 2025Article
- Advancing synthesis-free and enzyme-free rewritable DNA memory through frameshift encoding and nanopore duplex interruption decoding.PNAS nexus · 2025Article
- Hierarchical access to encoded data on DNA nanostructures using administrator and user keys.Nucleic acids research · 2025Article
- DNA storage: The future direction for medical cold data storage.Synthetic and systems biotechnology · 2025Review
- A Programmed DNA Dynamic Assembly-Guided Molecular Amplifier for Authentic Information Decryption.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- De novo non-canonical nanopore basecalling enables private communication using heavily-modified DNA data at single-molecule level.Nature communications · 2025Article
- Hybrid DNA Origami - Graphene Platform for Electrically-Gated Nanoscale Motion.Advanced materials interfaces · 2025Article
- Engineering a custom-sized DNA scaffold for more efficient DNA origami-based nucleic acid data storage.Synthetic biology (Oxford, England) · 2025Article
- A primordial DNA store and compute engine.Nature nanotechnology · 2024Article
- A Novel DNA-Based Dual-Mode Data Storage System with Interrelated Concise and Detailed Data.Small science · 2024Article
- Minimizing Structural Heterogeneity in DNA Self-Assembled Dye Templating via DNA Origami-Tuned Conformations.Langmuir : the ACS journal of surfaces and colloids · 2024Article
- DNA as a universal chemical substrate for computing and data storage.Nature reviews. Chemistry · 2024Review
- Ion beam processing of DNA origami nanostructures.Beilstein journal of nanotechnology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA is a compelling alternative to non-volatile information storage technologies due to its information density, stability, and energy efficiency. Previous studies have used artificially synthesized DNA to store data and automated next-generation sequencing to read it back. Here, we report digital Nucleic Acid Memory (dNAM) for applications that require a limited amount of data to have high information density, redundancy, and copy number. In dNAM, data is encoded by selecting combinations of single-stranded DNA with (1) or without (0) docking-site domains. When self-assembled with scaffold DNA, staple strands form DNA origami breadboards. Information encoded into the breadboards is read by monitoring the binding of fluorescent imager probes using DNA-PAINT super-resolution microscopy. To enhance data retention, a multi-layer error correction scheme that combines fountain and bi-level parity codes is used. As a prototype, fifteen origami encoded with 'Data is in our DNA!\n' are analyzed. Each origami encodes unique data-droplet, index, orientation, and error-correction information. The error-correction algorithms fully recover the message when individual docking sites, or entire origami, are missing. Unlike other approaches to DNA-based data storage, reading dNAM does not require sequencing. As such, it offers an additional path to explore the advantages and disadvantages of DNA as an emerging memory material.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.